J. Lum

Metabolic Vulnerabilities of Temozolomide-Resistant Glioblastoma Cells: Implications for Targeted Therapies and Overcoming Chemoresistance

The paper identifies metabolic vulnerabilities in TMZ-resistant glioblastoma cells, showing that iron reduction enhances the efficacy of TMZ through mechanisms involving Hif1, autophagy, and ROS.

Proliferative and quiescent human gastric cancer stem-like cells are associated with differential chemoresistance and patient mortality

This study identifies two stem-like gastric cancer subpopulations with distinct chemoresistance and survival outcomes using scRNA-seq and organoid models.

Disulfiram inhibits M. tuberculosis growth by altering methionine pool, redox status and host-immune response

This study identifies disulfiram as a novel inhibitor of Mtb's methionine biosynthesis, showing anti-tubercular effects through redox disruption and immune modulation.

Metformin enhances anti-mycobacterial responses by educating immunometabolic circuits of CD8+ T cells

This study shows metformin improves anti-mycobacterial responses by enhancing metabolic and functional properties of CD8+ T cells in mice and humans.

Host cholesterol dependent activation of VapC12 toxin enriches persister population during Mycobacterium tuberculosis infection

This study identifies cholesterol-dependent activation of the VapC12 toxin in Mycobacterium tuberculosis as a mechanism that increases persister formation during infection.

Histone acetylome-wide association study of tuberculosis

This study conducts a histone acetylome-wide association study (HAWAS) of tuberculosis, identifying differentially acetylated loci and their association with immune phenotypes.