Author

L. Krasny

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biochemistry· 2 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:bacteria (other)· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2

Frequent Co-Authors

D. Kalalova· 2 shared P. H. Huang· 2 shared S. E. Acton· 2 shared V. G. Martinez· 2 shared A. Arthur· 1 shared A. C. Benjamin· 1 shared A. Jenks· 1 shared A. Nuss· 1 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersMicrobiology

D. Kalalova

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

The alternative sigma factor SigN of Bacillus subtilis is intrinsically toxic

A. T. Burton, D. Kalalova, E. V. Snider, L. Krasny, D. B. Kearns

This study shows that the alternative sigma factor SigN of Bacillus subtilis is intrinsically toxic when overexpressed, leading to cell death by outcompeting the vegetative sigma factor SigA for RNA polymerase core binding.

bioRxiv · Mar 22, 2023 · PreprintMicrobiology

Proteomic profiling identifies co-regulated expression of splicing factors as a characteristic feature of intravenous leiomyomatosis

L. Krasny, C. Wilding, E. Perkins, A. Arthur, N. Guljar, A. Jenks, C. Fisher, I. Judson, K. Thway, R. Jones, P. Huang

This study identifies co-regulated splicing factor expression as a defining feature of intravenous leiomyomatosis through proteomic analysis.

bioRxiv · Mar 17, 2022Cancer Biology

Quasi-essentiality of RNase Y in Bacillus subtilis is caused by its critical role in the control of mRNA homeostasis

M. Benda, S. Woelfel, K. Gunka, S. Klumpp, A. Poehlein, D. Kalalova, H. Sanderova, R. Daniel, L. Krasny, J. Stuelke

This study shows that RNase Y is quasi-essential in Bacillus subtilis due to its role in mRNA homeostasis, as suppressor mutations in RNA polymerase subunits alleviate its deletion effects.

bioRxiv · May 20, 2020Microbiology

A mouse SWATH-MS reference spectral library enables deconvolution of species-specific proteomic alterations in human tumour xenografts

L. Krasny, P. Bland, J. Burns, N. C. Lima, P. T. Harrison, L. Pacini, M. L. Elms, J. Ning, V. G. Martinez, Y.-R. Yu, S. E. Acton, P.-C. Ho, F. Calvo, A. Swain, B. A. Howard, , P. H. Huang

The paper develops a mouse SWATH-MS spectral library and a deconvolution method to analyze proteomic changes in human tumor xenografts, revealing host-tumor interactions.

bioRxiv · Feb 3, 2020Biochemistry

The alarmone (p)ppGpp is part of the heat shock response of Bacillus subtilis

H. Schäfer, B. Beckert, W. Steinchen, A. Nuss, M. Beckstette, I. Hantke, P. Sudzinova, L. Krasny, V. Kaever, P. Dersch, G. Bange, D. Wilson, K. Turgay

This study shows that (p)ppGpp, a bacterial alarmone, mediates the heat shock response in B. subtilis by reducing translation and enhancing stress tolerance.

bioRxiv · Jul 1, 2019Microbiology

Analysis of Nucleotide Pools in Bacteria Using HPLC-MS in HILIC Mode

E. Zbornikova, Z. Knejzlik, V. Hauryliuk, L. Krasny, D. Rejman

The paper presents a method to measure intracellular nucleotide concentrations in bacteria using HPLC-HILIC with UV and MS detection, showing reliable quantification of >25 molecular species.

bioRxiv · Jun 2, 2019Microbiology

Conduit integrity is compromised during acute lymph node expansion

V. G. Martinez, V. Pankova, L. Krasny, T. Singh, I. J. White, A. C. Benjamin, S. Dertschnig, H. L. Horsnell, J. Kriston-Vizi, J. J. Burden, P. H. Huang, C. J. Tape, S. E. Acton

This study investigates how conduit integrity in lymph nodes changes during acute expansion, finding that while the structure is disrupted, FRC-FRC contacts remain intact and antigen flow becomes leaky.

bioRxiv · Mar 21, 2019Immunology

“CapZyme-Seq” comprehensively defines promoter-sequence determinants for RNA 5’ capping with NAD+

I. O. Vvedenskaya, J. G. Bird, Y. Zhang, Y. Zhang, X. Jiao, I. Barvik, L. Krasny, M. Kiledjian, D. M. Taylor, R. H. Ebright, B. E. Nickels

The paper introduces CapZyme-Seq to detect NCIN-capped RNA and identifies a consensus promoter sequence for NAD+ capping in E. coli.

bioRxiv · Dec 29, 2017Biochemistry