Author

S. Krishnaswamy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Organism:human· 4 Organism:mouse· 4 Approach:deep learning· 3 Research Focus:differential expression· 3 Approach:statistical model· 3 Research Focus:trajectory inference· 3 Assay:bulk RNA-seq· 2

Frequent Co-Authors

A. Tong· 2 shared A. Venkat· 2 shared C. E. Hendry· 2 shared D. Bhaskar· 2 shared M. Kuchroo· 2 shared A. Babic· 1 shared A. Bhutkar· 1 shared A. C. Koong· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersCancer Biology

A. Tong

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Revealing dynamic temporal trajectories and underlying regulatory networks with Cflows

X. Sun, S. Gupta, A. Tong, M. Kuchroo, D. Bhaskar, C. Liu, A. Venkat, B. Perez San Juan, L. Rangel, V. Rodriguez, J. G. Lock, C. Chaffer, S. Krishnaswamy

Cflows infers continuous cell state transitions and gene regulatory networks from static scRNA-seq data, revealing ESRRA as a key driver of tumor formation.

bioRxiv · Mar 28, 2023 · PreprintCancer Biology

Spatiotemporal coordination of stem cell behavior following alveolar injury

M. Chioccioli, S. Magruder, J. E. McDonough, J. Nouws, D. Gonzalez, L. Borriello, B. Traub, X. Ye, C. E. Hendry, D. Entenberg, S. Krishnaswamy, N. Kaminski, M. Sauler

This study tracks alveolar type 2 stem cell behavior after injury using live imaging and identifies distinct motility states and their regulation.

bioRxiv · Oct 28, 2022 · PreprintCell Biology

Trellis Single-Cell Screening Reveals Stromal Regulation of Patient-Derived Organoid Drug Responses

M. Ramos Zapatero, A. Tong, J. Sufi, P. Vlckova, F. Cardoso Rodriguez, C. Nattress, X. Qin, D. Hochhauser, S. Krishnaswamy, C. J. Tape

The paper develops Trellis, a method to analyze single-cell drug responses in PDOs and CAFs, revealing patient-specific apoptosis and CAF-mediated chemoprotection via YAP signaling.

bioRxiv · Oct 19, 2022 · PreprintCancer Biology

G2 stem cells orchestrate time-directed, long-range coordination of calcium signaling during skin epidermal regeneration

J. L. Moore, F. Gao, C. Matte-Martone, S. Du, E. Lathrop, S. Ganesan, L. Shao, D. Bhaskar, A. Cox, C. E. Hendry, B. A. Rieck, S. Krishnaswamy, V. Greco

The paper uses a new machine learning tool to analyze calcium signaling dynamics in epidermal stem cells during regeneration, revealing that G2 stem cells coordinate long-range signaling through gap junctions.

bioRxiv · Oct 12, 2021Cell Biology

A reservoir of stem-like CD8 T cells in the tumor-draining lymph node maintains the ongoing anti-tumor immune response

K. A. Connolly, M. Kuchroo, A. Venkat, A. Khatun, J. Wang, I. William, N. Hornick, B. Fitzgerald, M. Damo, M. Y. Kasmani, C. Cui, E. Fagerberg, I. Monroy, A. Hutchins, J. F. Cheung, , N. S. Joshi

The paper identifies a reservoir of stem-like CD8 T cells in tumor-draining lymph nodes that sustain anti-tumor immunity by maintaining TCF1 expression and resisting terminal differentiation.

bioRxiv · Jan 27, 2021Immunology

Endocrine-exocrine signaling drives obesity-associated pancreatic ductal adenocarcinoma

K. M. Chung, J. Singh, L. Lawres, K. J. Dorans, C. Garcia, D. B. Burkhardt, R. Robbins, A. Bhutkar, R. Cardone, X. Zhao, A. Babic, S. A. Vayrynen, A. Dias Costa, J. A. Nowak, D. T. Chang, , M. D. Muzumdar

This study shows obesity accelerates pancreatic cancer by altering the tumor microenvironment, with reversible effects through weight loss.

bioRxiv · Sep 26, 2019Cancer Biology