C. Langelier

BiP/GRP78 is a pro-viral factor for diverse dsDNA viruses that promotes the survival and proliferation of cells upon KSHV infection

This study identifies BiP/GRP78 as a pro-viral factor that promotes cell survival and proliferation during KSHV infection and inhibits other dsDNA viruses.

Global Absence and Targeting of Protective Immune States in Severe COVID-19.

The paper identifies that severe COVID-19 patients lack ISG-expressing cells and have antibodies that block their production, contrasting with mild cases.

Intestinal infection results in impaired lung innate immunity to secondary respiratory infection.

This study shows that prior intestinal infection with Salmonella Typhimurium increases susceptibility to respiratory Klebsiella pneumoniae infection due to altered neutrophil responses in the lungs.

Designing and implementing programmable depletion in sequencing libraries with DASHit

The paper introduces DASHit, a software tool that designs CRISPR-based depletion targets to reduce high-abundance sequences in sequencing libraries, demonstrating its effectiveness across three species.

Investigating Transfusion-Related Sepsis using Culture-Independent Metagenomic Sequencing

This study uses metagenomic sequencing to identify pathogens in transfusion-related sepsis cases, revealing a novel Acinetobacter species and demonstrating the utility of culture-independent methods.

FLASH: A next-generation CRISPR diagnostic for multiplexed detection of antimicrobial resistance sequences

FLASH is a CRISPR-based diagnostic method that enhances detection of low-abundance antimicrobial resistance sequences in metagenomic data.

Microbiome and Antimicrobial Resistance Gene Dynamics in International Travelers

This study uses metagenomic sequencing to track changes in gut microbiota and antimicrobial resistance genes in international travelers, finding increased resistance genes and Escherichia species without affecting microbial diversity.

A Metagenomic Comparison of Tracheal Aspirate and Mini-Bronchial Alveolar Lavage for Assessment of Respiratory Microbiota

This paper compares metagenomic sequencing of tracheal aspirates and mini-bronchial alveolar lavage to assess respiratory microbiota and develop diagnostic models for lower respiratory tract infections.

Pulmonary Metagenomic Sequencing Suggests Missed Infections in Immunocompromised Children

This study develops a metagenomic sequencing assay to detect missed pathogens in immunocompromised children, finding increased sensitivity for identifying potential pathogens in lung samples.

Metagenomics for chronic meningitis: clarifying interpretation and diagnosis

This study uses metagenomic next-generation sequencing of cerebrospinal fluid to identify pathogens in patients with subacute or chronic meningitis, using a z-score based scoring algorithm to distinguish true pathogens from environmental contaminants.