Author

C. Lopez-Otin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:clustering· 1 Assay:DNA methylation· 1

Frequent Co-Authors

A. C. Franco· 1 shared A. C. Real· 1 shared A. Carvalho· 1 shared A. F. Powers· 1 shared A. Leal· 1 shared A. Lopez-Guillermo· 1 shared A. Nakamura· 1 shared A. Queiros· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperPhysiology

A. C. Franco

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Ghrelin delays premature aging in Hutchinson-Gilford progeria syndrome

M. Ferreira-Marques, A. Carvalho, A. C. Franco, A. Leal, M. Botelho, S. Carmo-Silva, R. Aguas, L. Cortes, V. Lucas, A. C. Real, C. Lopez-Otin, X. Nissan, L. Pereira de Almeida, C. Cavadas, C. A. Aveleira

This study shows ghrelin improves cellular and organismal features of HGPS by promoting autophagy and clearing progerin, extending lifespan in a mouse model.

bioRxiv · May 2, 2023Physiology

miR-29 is an important driver of aging-related phenotypes

V. Swahari, A. Nakamura, E. Hollville, Y.-H. Hung, M. Kanke, C. L. Kurtz, X. M. Caravia, S. He, J. Krishnamurthy, S. Kapoor, V. Prasad, C. Flowers, M. Beck, J. Baran-Gale, N. Sharpless, , M. Deshmukh

This study identifies miR-29 as a key driver of aging-related phenotypes by showing its upregulation in aging models and its ability to induce aging traits when overexpressed.

bioRxiv · Nov 29, 2022Physiology

OMA1 mediates local and global stress responses against protein misfolding in CHCHD10 mitochondrial myopathy

M. K. Shammas, X. Huang, B. P. Wu, I. Song, N. Randolph, Y. Li, C. K. E. Bleck, D. Springer, C. Fratter, I. Barbosa, A. F. Powers, P. M. Quiros, C. Lopez-Otin, J. Poulton, D. P. Narendra

bioRxiv · Dec 21, 2021Cell Biology

The proliferative history shapes the DNA methylome of B-cell tumors and predicts clinical outcome

M. Duran-Ferrer, G. Clot, F. Nadeu, R. Beekman, T. Bauman, J. Nordlund, Y. Marincevic-Zuniga, G. Lonnerholm, A. Rivas, S. Martin, R. Ordonez, G. Castellano, M. Kulis, A. Queiros, L. Seung-Tae, , J. I. Martin-Subero

This study analyzes DNA methylation in B-cell tumors to show its relation to proliferative history and clinical outcomes, introducing a new mitotic clock for prognosis.

bioRxiv · Feb 6, 2020Cancer Biology