Author

Y.-H. Hung

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Plant Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:Arabidopsis· 2 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Organism:mouse· 2

Frequent Co-Authors

P. Sethupathy· 3 shared C. Zhang· 2 shared T.-F. Hsieh· 2 shared W. Xiao· 2 shared X.-Q. Zhang· 2 shared A. Bartels· 1 shared A. Nakamura· 1 shared B. C. E. Peck· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersPhysiology

P. Sethupathy

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Multi-omic study of genome-edited human colonoid models of colorectal cancer reveal genotype-specific patterns of microRNA regulation

J. W. Villanueva, F. C. Pan, E. J. Rice, Y.-H. Hung, M. Winnicki, S. Chen, C. G. Danko, P. Sethupathy

This study uses genome-edited human colonoids to identify genotype-specific miRNA regulation patterns in colorectal cancer, highlighting potential therapeutic targets.

bioRxiv · Jul 28, 2023 · PreprintCancer Biology

miR-29 is an important driver of aging-related phenotypes

V. Swahari, A. Nakamura, E. Hollville, Y.-H. Hung, M. Kanke, C. L. Kurtz, X. M. Caravia, S. He, J. Krishnamurthy, S. Kapoor, V. Prasad, C. Flowers, M. Beck, J. Baran-Gale, N. Sharpless, , M. Deshmukh

This study identifies miR-29 as a key driver of aging-related phenotypes by showing its upregulation in aging models and its ability to induce aging traits when overexpressed.

bioRxiv · Nov 29, 2022Physiology

Loss of Linker Histone H1 in the Maternal Genome Influences DEMETER-Mediated Demethylation and Affects the Endosperm DNA Methylation Landscape

T.-F. Hsieh, Q. Han, Y.-H. Hung, C. Zhang, A. Bartels, M. Rea, H. Yang, C. Park, X.-Q. Zhang, R. L. Fsicher, W. Xiao

This study shows that loss of maternal linker histone H1 in Arabidopsis facilitates DME-mediated demethylation in heterochromatin but has limited effects on endosperm gene transcription and imprinting.

bioRxiv · Oct 17, 2022Plant Biology

Vertical Sleeve Gastrectomy Induces Enteroendocrine Cell Differentiation of Intestinal Stem Cells Through Farnesoid X Receptor Activation

K.-S. Kim, B. C. E. Peck, Y.-H. Hung, K. L. Koch-Laskowski, L. Wood, P. H. Dedhia, J. R. Spence, R. J. Seeley, P. Sethupathy, D. A. Sandoval

This study shows vertical sleeve gastrectomy increases enteroendocrine cells via FXR activation in intestinal stem cells, using RNAseq and organoid experiments.

bioRxiv · Apr 22, 2021 · PreprintPhysiology

The Catalytic Core of DEMETER Guides Active DNA Demethylation in Arabidopsis

C. Zhang, Y.-H. Hung, X.-Q. Zhang, D. Zhang, J. M. Frost, F. Liu, W. Xiao, L. M. Iyer, L. Aravind, J. H. Huh, R. L. Fischer, T.-F. Hsieh

This study identifies the catalytic core of DME as essential for active DNA demethylation in Arabidopsis, showing that the N-terminus is required for heterochromatin demethylation and specificity.

bioRxiv · May 1, 2019Plant Biology