M. Peifer

The Dilute domain of Canoe is not essential for Canoe's role in linking adherens junctions to the cytoskeleton but contributes to robustness of morphogenesis

Exploring the evolution and function of Canoes intrinsically disordered region in linking cell-cell junctions to the cytoskeleton during embryonic morphogenesis

The paper investigates the evolution and function of the intrinsically disordered region (IDR) of Canoe in linking cell-cell junctions to the cytoskeleton during Drosophila embryonic development.

Polychaetoid/ZO-1 strengthens cell junctions under tension while localizing differently than core adherens junction proteins

The paper investigates the role of Drosophila Polychaetoid/ZO-1 in strengthening cell junctions under tension and its distinct localization compared to core adherens junction proteins.

Functional synapses between small cell lung cancer and glutamatergic neurons

This study identifies glutamatergic synaptic interactions between SCLC cells and neurons, showing that these interactions support tumor growth and can be targeted therapeutically.

NEMO- and RelA-dependent NF-kB Signaling Promotes Small Cell Lung Cancer

This study identifies the role of NEMO- and RelA-dependent NF-κB signaling in promoting small cell lung cancer and suggests it as a therapeutic target.

Rap1 uses Canoe-dependent and Canoe-independent mechanisms to regulate apical contractility and allow embryonic morphogenesis without tissue disruption

This study identifies Canoe-dependent and Canoe-independent mechanisms by which Rap1 regulates apical contractility and morphogenesis in Drosophila without disrupting tissue integrity.

Multivalent interactions make adherens junction-cytoskeletal linkage robust during morphogenesis

The paper investigates how multivalent interactions contribute to the robustness of adherens junction-cytoskeletal linkage during Drosophila morphogenesis.

Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes

This study characterizes intra-tumor heterogeneity across 2,658 human cancer genomes, identifying subclonal mutations and evolutionary patterns across 38 cancer types.

A role for a micron-scale supramolecular myosin array in adherens junction cytoskeletal assembly

The paper investigates how epithelial cells assemble actomyosin structures at cell-cell junctions, finding that myosin self-assembly, not actin pathways, drives actin bundling and polarization.

Loss of TP53 mediates suppression of Macrophage Effector Function via Extracellular Vesicles and PDL1 towards Resistance against Chemoimmunotherapy in B-cell malignancies

This paper identifies that TP53 loss in B-cell lymphoma leads to resistance against chemoimmunotherapy by suppressing macrophage effector function through PDL1-expressing extracellular vesicles.

Abelson kinases intrinsically disordered linker plays important roles in protein function and protein stability

The study investigates the role of the intrinsically disordered linker in Abelson kinase, showing its essential functions in protein stability and embryonic development in Drosophila.

Wnt Regulation: Exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex

The paper investigates Wnt signaling by examining Axin-Dishevelled interactions and the recruitment of the SCF E3 ubiquitin ligase to the destruction complex, revealing dynamic roles of Axin and Dishevelled.

In vitro model for resistance in oncogene-dependent tumors at the limit of radiological detectability

The paper develops an in vitro model to study resistance mechanisms in oncogene-dependent tumors and shows that combining drugs targeting multiple resistance pathways can inhibit resistant and drug-tolerant cell growth.

The Crk adapter protein is essential for Drosophila embryogenesis, where it regulates multiple actin-dependent morphogenic events

This study shows Crk is essential for Drosophila embryogenesis, regulating actin dynamics in mitosis, wound healing, and axon patterning.

The Drosophila Afadin and ZO-1 homologs Canoe and Polychaetoid act in parallel to maintain epithelial integrity when challenged by adherens junction remodeling

This study shows Canoe and Polychaetoid work together to maintain epithelial integrity during junction remodeling in Drosophila embryos.

Centrosome Loss Triggers A Transcriptional Program To Counter Apoptosis-Induced Oxidative Stress

The paper investigates the transcriptional response to centrosome loss in Drosophila cells, identifying JNK signaling activation and redox regulation as key mechanisms to counter oxidative stress and cell death.

The evolutionary history of 2,658 cancers

This study uses whole-genome sequencing of cancer samples to reconstruct the evolutionary history of 39 cancer types, identifying early and late-stage mutational patterns and driver genes.

LITE microscopy: a technique for high numerical aperture, low photobleaching fluorescence imaging

The paper introduces LITE microscopy, a technique that improves resolution and brightness while reducing photodamage in fluorescence imaging.