Insulin determines the effects of TGF-beta on HNF4alpha transcription and epithelial-to-mesenchymal transition in hepatocytes
R. Feng, C. Tong, T. Lin, H. Liu, C. Shao, Y. Li, C. Sticht, K. Kan, X. Li, R. Liu, S. Wang, S. Wang, S. Munker, H. Niess, C. Meyer, , H.-L. Weng
This study shows insulin prevents TGF-beta-induced EMT in hepatocytes by inhibiting SMAD2/3 binding to C/EBP and SNAI1 promoters, maintaining HNF4 expression.
bioRxiv · Jan 12, 2023 · PreprintCell Biology