C. T. Trinh

This paper develops a high-throughput microbial screening platform to identify AATs for selective designer ester biosynthesis, demonstrating its effectiveness with specific AAT variants.

This study identifies and disrupts endogenous esterases in Clostridium thermocellum to enhance isobutyl acetate production from cellulose by reducing ester hydrolysis.

This study identifies the genetic basis of thiamine auxotrophy in Yarrowia lipolytica and engineers a thiamine-prototrophic strain with enhanced lipid production.

This study introduces ModCell2, a framework for modular cell engineering that optimizes genetic modifications to balance modularity, performance, and robustness in production strains.

This study engineered Yarrowia lipolytica to tolerate high concentrations of ionic liquids by enhancing sterol content in cell membranes, enabling robust growth in up to 18% [EMIM][OAc].

This paper describes the engineering of a microbial pathway using a novel P450 fatty acid decarboxylase to produce odd-chain terminal alkenes from glucose, achieving a 2.8-fold increase in yield through redox system optimization.

This study identifies native pentose-specific transporters in Yarrowia lipolytica that enhance xylose and arabinose assimilation, revealing a dormant pentose metabolism pathway.

This study evaluates the toxicity of 32 fermentative metabolites on E. coli growth under anaerobic conditions, identifying factors like carbon chain length and hydrophobicity that influence toxicity.