Author

D.-d. Chen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:zebrafish· 2 Assay:cryo-EM· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1 Organism:yeast· 1

Frequent Co-Authors

C. Zhang· 2 shared L.-F. Lu· 2 shared S. Li· 2 shared X.-Y. Zhou· 2 shared Z.-C. Li· 2 shared B.-J. Cui· 1 shared C.-H. Yun· 1 shared C.-J. Zhou· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersImmunology

C. Zhang

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Author profile →

3 papers

Recent·Most cited

Fish CDK2 recruits Dtx4 to degrade TBK1 through ubiquitination in the antiviral response

L.-F. Lu, C. Zhang, Z.-C. Li, B.-J. Cui, Y.-Y. Wang, K.-J. Han, X. Xu, C.-J. Zhou, X.-Y. Zhou, Y. Wu, N. Xu, X.-L. Yang, D.-D. Chen, X. Li, L. Zhou, S. Li

This study shows that fish CDK2 recruits Dtx4 to ubiquitinate and degrade TBK1, reducing IFN expression and enhancing antiviral resistance.

bioRxiv · Apr 23, 2024Immunology

Structure of a fungal 1,3-β-glucan synthase

C.-R. Zhao, Z.-L. You, D.-d. Chen, J. Hang, Z.-B. Wang, L.-X. Wang, P. Zhao, J. Qiao, C.-H. Yun, L. Bai

This study determines the cryo-EM structure of Saccharomyces cerevisiae 1,3-β-glucan synthase Fks1, revealing its catalytic mechanism and the role of disulfide bonds in enzymatic activity.

bioRxiv · Mar 19, 2023Biophysics

Grass Carp Reovirus (GCRV) Giving Its All to Suppress IFN Production by Countering MAVS-TBK1 Activation .

L.-F. Lu, Z.-C. Li, C. Zhang, X.-y. Zhou, Y. Zhou, J.-Y. Jiang, D.-d. Chen, S. Li, Y.-A. Zhang

This paper identifies how GCRV proteins interact with fish RLR factors to suppress MAVS-TBK1 signaling and reduce IFN expression, revealing a unique fish virus evasion mechanism.

bioRxiv · Oct 3, 2019Immunology