Author

E. Goodwin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Z. Wec· 3 shared J. M. Dye· 3 shared K. Chandran· 3 shared L. M. Walker· 3 shared A. S. Herbert· 2 shared A. S. Wirchnianski· 2 shared B. M. Gunn· 2 shared C. L. Moyer· 2 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMicrobiology

A. Z. Wec

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Influenza virus antibodies inhibit antigen-specific de novo B cell responses in mice

E. Goodwin, J. S. Gibbs, j. yewdell, L. C. Eisenlohr, S. E. Hensley

This study shows that pre-existing antibodies inhibit de novo B cell responses to influenza antigens in mice, but not to other vaccine antigens.

bioRxiv · Apr 12, 2024 · PreprintImmunology

The DHODH Inhibitor PTC299 Arrests SARS-CoV-2 Replication and Suppresses Induction of Inflammatory Cytokines

J. Luban, R. Sattler, E. Muhlberger, J. D. Graci, L. Cao, M. Weetall, C. Trotta, J. M. Colacino, S. Bavari, C. Strambio-De-Castillia, E. L. Suder, Y. Wang, V. Soloveva, K. Cintron-Lue, N. A. Naryshkin, , S. Peltz

This paper evaluates PTC299's ability to inhibit SARS-CoV-2 replication and reduce inflammatory cytokine production in tissue culture models.

bioRxiv · Aug 5, 2020Immunology

Human CD4+CD103+ cutaneous resident memory T cells are found in the circulation of healthy subjects

M. M. Klicznik, P. A. Morawski, B. Höllbacher, S. Varkhande, S. Motley, L. Kuri-Cervantes, E. Goodwin, M. D. Rosenblum, S. A. Long, G. Brachtl, T. Duhen, M. Betts, D. Campbell, I. K. Gratz

The paper identifies human CD4+CD103+ cutaneous resident memory T cells in circulation and shows they can migrate to distant skin sites.

bioRxiv · Mar 14, 2019 · PreprintImmunology

Human antibody cocktail deploys multiple functions to confer pan-ebolavirus protection

A. Z. Wec, Z. A. Bornholdt, S. He, A. S. Herbert, E. Goodwin, A. S. Wirchnianski, B. M. Gunn, Z. Zhang, W. Zhu, G. Liu, D. M. Abelson, C. L. Moyer, R. K. Jangra, R. M. James, R. R. Bakken, , K. Chandran

This paper develops a human antibody cocktail, MBP134, that provides broad protection against multiple ebolaviruses, showing enhanced efficacy in guinea pigs compared to individual antibodies.

bioRxiv · Aug 20, 2018Microbiology

Two-antibody pan-ebolavirus cocktail confers broad therapeutic protection in ferrets and nonhuman primates

Z. A. Bornholdt, A. S. Herbert, C. E. Mire, S. He, R. W. Cross, A. Z. Wec, D. M. Abelson, J. B. Geisbert, R. M. James, M. N. Rahim, W. Zhu, V. Borisevich, L. Banadyga, B. M. Gunn, K. N. Agans, , J. M. Dye

This paper demonstrates that a two-antibody cocktail (MBP134AF) provides broad therapeutic protection against multiple ebolaviruses in ferrets and nonhuman primates.

bioRxiv · Aug 19, 2018Microbiology

Structural Basis of Broad Ebolavirus Neutralization by a Human Survivor Antibody

B. R. West, A. Z. Wec, C. L. Moyer, M. L. Fusco, P. A. Illinykh, K. Huang, R. James, A. Herbert, S. Hui, A. S. Wirchnianski, E. Goodwin, M. J. Aman, L. M. Walker, J. M. Dye, A. Bukreyev, , E. O. Saphire

The paper determines the structure of a broadly neutralizing antibody against ebolavirus, identifies a conserved epitope, and explains factors affecting its activity against related viruses.

bioRxiv · Aug 19, 2018Immunology