M. Cole

Acarbose ameliorates Western diet-induced metabolic and cognitive impairments in the 3xTg mouse model of Alzheimer's disease

This study shows acarbose improves metabolic health and reduces cognitive deficits in Western diet-fed 3xTg mice, suggesting it may help prevent or delay Alzheimer's disease.

Spatial proteomic analysis of a lung cancer model reveals regulatory T cells attenuate KRAS-G12C inhibitor-induced immune responses

The paper identifies regulatory T cells as mediators of resistance to KRAS-G12C inhibitors and anti-PD-1 therapy through spatial proteomic analysis of lung cancer models.

Purine and pyrimidine synthesis differently affect the strength of the inoculum effect for aminoglycoside and B-lactam antibiotics.

The paper shows that purine and pyrimidine synthesis pathways influence the strength of the inoculum effect differently for beta-lactam and aminoglycoside antibiotics.

The impact of multiband and in-plane acceleration on white matter microstructure analysis

This study evaluates how multiband and in-plane acceleration affect white matter microstructure analysis in older adults with varying cognitive status, finding both benefits and drawbacks in reliability and group differences.

Potential selection and maintenance of manure-originated multi-drug resistant plasmids at sub-clinical antibiotic concentrations

This study determines the minimum selection concentrations of antibiotics for manure-originated multi-drug resistant plasmids in E. coli, showing they can be maintained in environmentally relevant concentrations.

Therapeutic KRASG12C inhibition drives effective interferon-mediated anti-tumour immunity in immunogenic lung cancers

KRASG12C inhibition enhances anti-tumour immunity in immunogenic lung cancers by upregulating interferon signaling through Myc repression, but only synergizes with immune checkpoint blockade in highly immunogenic models.

The time to peak blood bicarbonate (HCO3-), pH, and strong ion difference (SID) following sodium bicarbonate (NaHCO3) ingestion in highly trained adolescent swimmers

This study examines the time to peak blood bicarbonate, pH, and strong ion difference after sodium bicarbonate ingestion in adolescent swimmers, finding no significant differences in peak times but suggesting potential practical differences.

Characterisation of tumour immune microenvironment remodelling following oncogene inhibition in preclinical studies using an optimised imaging mass cytometry workflow

The paper optimises an imaging mass cytometry workflow to study TME remodelling in mouse models after KRAS G12C inhibitor treatment.

Inhalable textile microplastic fibers impair airway epithelial growth

This study shows nylon microplastic fibers impair airway epithelial growth in organoids, likely due to leaching components, highlighting risks of indoor exposure.

Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis

This study compares single-cell transcriptomes of blood and cerebrospinal fluid leukocytes in multiple sclerosis, identifying compartment-specific changes in cell types and transcriptional diversity.

Effects of Δ9-tetrahydrocannabinol (THC) vapor inhalation in Sprague-Dawley and Wistar rats

This study compares hypothermic and anti-nociceptive effects of inhaled THC between Sprague-Dawley and Wistar rats, finding strain differences in hypothermia despite similar plasma THC levels.

Effects of Nicotine and THC Vapor Inhalation Administered by An Electronic Nicotine Delivery System (ENDS) in Male Rats

This study examines the effects of nicotine and THC vapor from ENDS on male rats, showing nicotine-induced locomotion and hypothermia, with additive and opposing effects when combined with THC.

Effects Of Δ9-THC And Cannabidiol Vapor Inhalation In Male And Female Rats

This study compares thermoregulatory and locomotor responses to THC, CBD, and their combination inhaled via vapor in male and female rats, finding equivalent effects with subtle sex differences.