Author

E. W. Settles

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Organism:chicken / avian· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

P. S. Keim· 3 shared S. A. Jaramillo· 3 shared A. N. Jones· 2 shared C. T. French· 2 shared H. E. Nunnally· 2 shared K. E. Zarn· 2 shared N. E. Stone· 2 shared S. Knudsen· 2 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

P. S. Keim

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Stenoparib, an inhibitor of cellular poly (ADP-ribose) polymerases (PARPs), blocks in vitro replication of SARS-CoV-2 variants

K. E. Zarn, S. A. Jaramillo, A. R. Zapata, N. E. Stone, A. N. Jones, H. E. Nunnally, E. W. Settles, K. Ng, P. S. Keim, S. Knudsen, P. M. Nuijten, A. S. Tijsma, C. T. French

This study shows that stenoparib inhibits SARS-CoV-2 variants in vitro, with EC50 values ranging from 4.1 to 24.1 M, and combination with remdesivir enhances antiviral effects.

bioRxiv · Nov 3, 2021Microbiology

Dual roles of a novel oncolytic viral vector-based SARS-CoV-2 vaccine: preventing COVID-19 and treating tumor progression

M. A. Caligiuri, J. Yu, Y. Sun, W. Dong, L. Tian, Y. Rao, C. Qin, S. A. Jaramillo, E. W. Settles, S. Ma, J. Zhang, K. Yu, B. Xu, J. Yan, R. Ma, , P. Feng

This paper develops an oncolytic viral vector-based vaccine that prevents COVID-19 and treats tumor progression in preclinical models.

bioRxiv · Jun 7, 2021 · PreprintMicrobiology

Stenoparib, an inhibitor of cellular poly (ADP-ribose) polymerase (PARP), blocks replication of the SARS-CoV-2 human coronavirus in vitro.

N. E. Stone, S. A. Jaramillo, A. N. Jones, A. J. Vazquez, M. Martz, L. M. Versluis, M. O. Raniere, H. E. Nunnally, K. E. Zarn, R. Nottingham, J. W. Sahl, D. M. Wagner, S. Knudsen, E. W. Settles, P. S. Keim, C. T. French

This paper evaluates stenoparib, a PARP inhibitor, for antiviral activity against SARS-CoV-2 and other coronaviruses in vitro, showing dose-dependent suppression and potential synergy with remdesivir.

bioRxiv · Nov 12, 2020 · PreprintMicrobiology

Caprine humoral response to Burkholderia pseudomallei antigens during acute melioidosis from aerosol exposure

J. Yi, M. F. Simpanya, E. W. Settles, A. B. Shannon, K. Hernandez, L. Pristo, M. Keener, H. Hornstra, J. D. Busch, C. Soffler, P. J. Brett, B. J. Currie, R. A. Bowen, A. Tuanyok, P. Keim

This study characterizes the caprine humoral immune response to Burkholderia pseudomallei during aerosol-induced melioidosis, identifying immunogenic proteins that may serve as diagnostic biomarkers.

bioRxiv · Sep 17, 2018Immunology