P. Feng

Glutamate (E299) is a key residue in the evolutionarily divergence of the SAM-dependent methyltransferases DnrK and RdmB in anthracycline biosynthesis

The paper identifies residue E299 as critical for the divergent catalytic functions of DnrK and RdmB in anthracycline biosynthesis, revealing distinct mechanisms for 10-hydroxylation and 4-O-methylation.

A 10-valent composite mRNA vaccine against both influenza and COVID-19

This paper introduces FLUCOV-10, a 10-valent mRNA vaccine targeting influenza and SARS-CoV-2, showing robust immune responses and complete protection in mice against multiple strains.

Unraveling the gut microbiota of Tibetan chickens: insights into highland adaptation and ecological advantages

This study compares the gut microbiota of Tibetan chickens from different environments to identify adaptations to high-altitude conditions.

METTL16 Controls Kaposi's Sarcoma-Associated Herpesvirus Replication by Regulating S-Adenosylmethionine Cycle

This study shows METTL16 suppresses KSHV lytic replication by regulating the SAM cycle and redox homeostasis.

Mining multi-omics data for molecular subtyping in gliomas facilitates precise clinical treatment

This study identifies glioma subtypes using multi-omics data and finds that cluster A has better prognosis and lower proliferation, while cluster B has worse prognosis and higher EMT activation.

Hardware-Efficient Compression of Neural Multi-Unit Activity

This paper develops hardware-efficient compression for neural multi-unit activity signals, reducing bandwidth and power usage while maintaining decoding performance.

The Roles of APOBEC-mediated RNA Editing in SARS-CoV-2 Mutations, Replication, and Fitness

The paper shows host APOBEC3A, APOBEC1, and APOBEC3G edit SARS-CoV-2 RNA, promoting viral replication and suggesting APOBEC-mediated mutations contribute to viral evolution and new strain emergence.

Dual roles of a novel oncolytic viral vector-based SARS-CoV-2 vaccine: preventing COVID-19 and treating tumor progression

This paper develops an oncolytic viral vector-based vaccine that prevents COVID-19 and treats tumor progression in preclinical models.

Targeting CTP Synthetase 1 to Restore Interferon Induction and Impede Nucleotide Synthesis in SARS-CoV-2 Infection

This study identifies CTPS1 as a target for antiviral therapy by showing it suppresses interferon induction and promotes viral replication in SARS-CoV-2 infection.

Autonomous Wireless System for Robust and Efficient Inductive Power Transmission to Multi-Node Implants

This paper presents two strategies for improving wireless power transmission to multi-node implants: a scalable resonator array and a self-regulated power management circuit.

Deubiquitylation and stabilization of p21 by USP11 is critical for cell cycle progression and DNA damage responses

This study identifies USP11 as a deubiquitylase that stabilizes p21, affecting cell cycle progression and DNA damage responses.