Author

F. C. Pan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

S. Chen· 4 shared B. R. tenOever· 2 shared C. G. Danko· 2 shared D. D. Ho· 2 shared D. Xu· 2 shared H. Wang· 2 shared J. W. Villanueva· 2 shared L. Yang· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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4 shared papersCancer Biology

S. Chen

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Multi-omic study of genome-edited human colonoid models of colorectal cancer reveal genotype-specific patterns of microRNA regulation

J. W. Villanueva, F. C. Pan, E. J. Rice, Y.-H. Hung, M. Winnicki, S. Chen, C. G. Danko, P. Sethupathy

This study uses genome-edited human colonoids to identify genotype-specific miRNA regulation patterns in colorectal cancer, highlighting potential therapeutic targets.

bioRxiv · Jul 28, 2023 · PreprintCancer Biology

Genome edited colorectal cancer organoid models reveal distinct microRNA activity patterns across different mutation profiles

J. W. Villanueva, L. Kwong, T. Han, S. A. Martinez, F. C. Pan, M. T. Shanahan, M. Kanke, S. Chen, L. E. Dow, C. G. Danko, P. Sethupathy

The paper uses genome-edited colorectal cancer organoids to identify microRNA expression patterns linked to specific mutation profiles and shows miR-24-3p's role in promoting cancer cell survival.

bioRxiv · Dec 13, 2021 · PreprintCancer Biology

Identification of Candidate COVID-19 Therapeutics using hPSC-derived Lung Organoids

Y. Han, L. Yang, X. Duan, F. Duan, B. E. Nilsson-Payant, T. M. Yaron, P. Wang, X. Tang, T. Zhang, Z. Zhao, Y. Bram, D. Redmond, S. Houghton, D. Nguyen, D. Xu, , S. Chen

This study uses hPSC-derived lung organoids to identify FDA-approved drugs that inhibit SARS-CoV-2 entry and reduce infection in a model of human COVID-19.

bioRxiv · May 5, 2020 · PreprintMicrobiology

Identification of Drugs Blocking SARS-CoV-2 Infection using Human Pluripotent Stem Cell-derived Colonic Organoids

X. Duan, Y. Han, L. Yang, B. Nilsson, P. Wang, T. Zhang, X. Wang, D. Xu, J. Z. Xiang, s. uhl, Y. Huang, H. Chen, H. Wang, B. R. tenOever, R. E. Schwartz, , T. R. Evans

This study uses human pluripotent stem cell-derived colonic organoids to identify drugs that block SARS-CoV-2 infection, finding mycophenolic acid and quinacrine dihydrochloride effective in vitro and in vivo.

bioRxiv · May 2, 2020 · PreprintMicrobiology