Author

Y. Bram

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Immunology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 6 Assay:bulk RNA-seq· 4 Research Focus:host-pathogen & immune response· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Assay:spatial transcriptomics· 2 Approach:statistical model· 2

Frequent Co-Authors

R. E. Schwartz· 4 shared V. Chandar· 3 shared A. C. Borczuk· 2 shared B. R. tenOever· 2 shared C. Meydan· 2 shared C. Mozsary· 2 shared F. Muecksch· 2 shared J. Foox· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersMicrobiology

R. E. Schwartz

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Lethal COVID-19 Associates With RAAS-Induced Inflammation For Multiple Organ Damage Including Mediastinal Lymph Nodes

J. W. Guarnieri, M. Topper, K. Beigel, J. A. Haltoom, A. Chadburn, J. Frere, J. An, H. Cope, A. Borczuk, S. Sinha, C. Lim, J. Kim, J. Park, C. Meydan, J. Foox, , K Clark

This study identifies non-canonical genes linked to RAAS overactivation in lethal COVID-19, causing multi-organ damage and mediastinal lymph node dysfunction.

bioRxiv · Oct 8, 2023 · PreprintImmunology

SARS-CoV-2 infection results in lasting and systemic perturbations post recovery

J. J. Frere, R. A. Serafini, K. D. Pryce, M. Zazhytska, K. Oishi, I. Golynker, M. Panis, J. Zimering, S. Horiuchi, D. A. Hoagland, R. Moller, A. Ruiz, J. B. Overdevest, A. Kodra, P. D. Canoll, , B. tenOever

This study compares short- and long-term systemic responses to SARS-CoV-2 and IAV in golden hamsters, finding persistent inflammation in olfactory tissues post-recovery.

bioRxiv · Jan 18, 2022Microbiology

SARS-CoV-2 Infects Syncytiotrophoblast and Activates Inflammatory Responses in the Placenta

L. B. Argueta, L. A. Lacko, Y. Bram, T. Tada, L. Carrau, T. Zhang, S. Uhl, B. C. Lubor, V. Chandar, C. Gil, W. Zhang, B. Dodson, J. Bastiaans, M. Prabhu, C. M. Salvatore, , H. Stuhlmann

This study investigates SARS-CoV-2 infection in placentas from infected pregnant women, finding that the virus infects syncytiotrophoblast cells and triggers maternal immune cell infiltration.

bioRxiv · Jun 1, 2021Cell Biology

Coagulation factors directly cleave SARS-CoV-2 spike and enhance viral entry

E. R. Kastenhuber, J. A. Jaimes, J. L. Johnson, M. Mercadante, F. Muecksch, Y. Weisblum, Y. Bram, R. E. Schwartz, G. R. Whittaker, L. C. Cantley

This study shows coagulation factors like factor Xa and thrombin directly cleave SARS-CoV-2 spike, enhancing viral entry, and suggests anticoagulation could reduce infection.

bioRxiv · Mar 31, 2021Microbiology

Systemic Tissue and Cellular Disruption from SARS-CoV-2 Infection revealed in COVID-19 Autopsies and Spatial Omics Tissue Maps

J. Park, J. Foox, T. Hether, D. Danko, S. Warren, Y. Kim, J. Reeves, D. J. Butler, C. Mozsary, J. Rosiene, A. Shaiber, E. Afshinnekoo, M. MacKay, Y. Bram, V. Chandar, , Schwar

This study identifies systemic tissue and cellular disruption from SARS-CoV-2 infection using autopsy and spatial omics data, showing tissue-specific damage and transcriptional changes.

bioRxiv · Mar 8, 2021 · PreprintMicrobiology

Evolution of Antibody Immunity to SARS-CoV-2

C. Gaebler, Z. Wang, J. C. C. Lorenzi, F. Muecksch, S. Finkin, M. Tokuyama, A. Cho, M. Jankovic, D. Schaefer-Babajew, T. Y. Oliveira, M. Cipolla, C. Viant, C. O. Barnes, A. Hurley, M. Turroja, , R. Patel

This study examines the evolution of antibody immunity to SARS-CoV-2 over time, finding that memory B cells evolve with increased potency and resistance to mutations.

bioRxiv · Nov 3, 2020Immunology

Identification of Candidate COVID-19 Therapeutics using hPSC-derived Lung Organoids

Y. Han, L. Yang, X. Duan, F. Duan, B. E. Nilsson-Payant, T. M. Yaron, P. Wang, X. Tang, T. Zhang, Z. Zhao, Y. Bram, D. Redmond, S. Houghton, D. Nguyen, D. Xu, , S. Chen

This study uses hPSC-derived lung organoids to identify FDA-approved drugs that inhibit SARS-CoV-2 entry and reduce infection in a model of human COVID-19.

bioRxiv · May 5, 2020 · PreprintMicrobiology