K.-C. Chang

An emerging PB2-627 polymorphism increases the pandemic potential of avian influenza virus by breaking through ANP32 host restriction in mammalian and avian hosts

This paper identifies a PB2-627V mutation in avian influenza viruses that enhances pandemic potential by overcoming host restriction through ANP32A proteins in both avian and mammalian hosts.

Myeloid-mesenchymal crosstalk drives Arg1-dependent profibrotic metabolism via ornithine in lung fibrosis

The paper identifies a myeloid-mesenchymal crosstalk pathway involving Arg1 and ornithine that drives profibrotic metabolism in lung fibrosis.

Junior scientists spotlight social bonds in seminars for diversity, equity, and inclusion in STEM

The paper analyzes seminar talks by junior scientists to assess how they discuss diversity, equity, and inclusion in STEM, finding common themes and intersectional identities.

Mapping enzyme catalysis with metabolomic biosensing

The paper introduces a method to sense enzyme product formation using host cell metabolism and mass spectrometry to map enzyme activity and mutagenesis effects.

SARS-CoV-2 spike RBD and nucleocapsid encoding DNA vaccine elicits T cell and neutralising antibody responses that cross react with variants

This paper designs a DNA vaccine encoding SARS-CoV-2 spike RBD and nucleocapsid proteins, showing strong T cell responses and cross-reactive neutralizing antibodies against variants in mice.

The long non-coding RNA MaTAR20 promotes mammary tumor growth by regulating angiogenesis pathways

This study identifies MaTAR20 as a lncRNA that promotes mammary tumor growth by regulating angiogenesis pathways, specifically through its interaction with Tnfsf15.

MaTAR25 LncRNA Regulates the Tensin1 Gene to Impact Breast Cancer Progression

This study identifies MaTAR25 and its human ortholog LINC01271 as lncRNAs that regulate Tns1 expression, impacting breast cancer progression through actin cytoskeleton and focal adhesion changes.

Linked optical and gene expression profiling of single cells at high throughput

This paper introduces a high-throughput platform that links optical and gene expression profiling of single cells, demonstrating accurate measurements from thousands of cells and characterizing DNA and RNA changes in Jurkat cells through the cell cycle.

An efficient timer and sizer of biomacromolecular motions

The paper develops an efficient method to estimate the time scales and sizes of slow protein motions using elastic network models and power laws validated by NMR data.