GLI1 facilitates rheumatoid arthritis by collaborative regulation of DNA methyltransferases
G. Ge, Q. Guo, Y. Zhou, W. Li, W. Zhang, J. Bai, Q. Wang, H. Tao, W. Wang, Z. Wang, M. Gan, Y. Xu, H. Yang, B. Li, D. Geng
This study shows GLI1 promotes rheumatoid arthritis by regulating DNA methyltransferases, leading to M1 macrophage polarization and osteoclast activation, and suggests GLI1 inhibitors as potential treatments.
bioRxiv · Feb 7, 2023Cell Biology