F. Pincet

A model for collagen secretion by intercompartmental continuities

The paper proposes a mechanical/entropic ratchet model explaining how procollagen is exported from the ER via TANGO1-dependent tunnels using molecular gradients of pH and HSP47.

Direct determination of oligomeric organization of integral membrane proteins and lipids from intact customizable bilayer

This paper develops a platform for analyzing integral membrane proteins and lipids in intact membranes using native mass spectrometry, showing how lipid binding and membrane composition affect protein function.

Vesicle capture by discrete self-assembled clusters of membrane-bound Munc13

This study shows that Munc13 forms self-assembled clusters which are necessary for vesicle capture, with cluster size and the C2C domain affecting efficiency.

TANGO1 membrane helices create a lipid diffusion barrier at curved membranes

The paper shows TANGO1 membrane helices form a lipid diffusion barrier at curved membranes to prevent mixing during secretory cargo transport.

CX3CL1 oligomerization is required for efficient CX3CR1-specific cell adherence

This study shows that CX3CL1 oligomerization is essential for its adhesive function, with the transmembrane domain driving oligomer formation and affecting cell adherence.

GABARAP Like-1 enrichment on membranes: Direct observation of trans-homo-oligomerization between membranes and curvature-dependent partitioning into membrane tubules.

This paper observes GABARAPL1-mediated membrane tethering and curvature-dependent partitioning using GUVs and micromanipulation.

Droplets bumpers as mechanical sensors for cell migration under confinement

This study uses oil emulsion droplets as mechanical sensors to measure cell forces during HL-60 cell migration under confinement, revealing acto-myosin contraction's role in obstacle crossing.