Author

I. Chen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Bioengineering· 1 Biophysics· 1 Cell Biology· 1 Microbiology· 1 Pharmacology & Toxicology· 1 Scientific Communication & Education· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1

Frequent Co-Authors

A. Ciling· 1 shared A. G. Stewart· 1 shared A. M. Gregus· 1 shared A. M. Syed· 1 shared A. Tang· 1 shared AI4ALL Student Cohort 2020· 1 shared B. Brown· 1 shared B. Vora· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperMicrobiology

A. Ciling

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

12/15-Lipoxygenases mediate neuropathic-like pain hypersensitivity in female mice

B. Brown, I. Chen, C. Miliano, L. B. Murdaugh, Y. Dong, K. A. Eddinger, T. L. Yaksh, M. D. Burton, M. Buczynski, A. M. Gregus

This study shows that 12/15-Lipoxygenases contribute to neuropathic-like pain hypersensitivity in female mice, with inhibitors reversing pain symptoms.

bioRxiv · Apr 4, 2024 · PreprintPharmacology & Toxicology

Regulation of virion production by the ORF8 signal peptide across SARS-CoV-2 variants

M. M. Khalid, I. Chen, F. S. Soveg, T. Y. Taha, T. Tabata, R. Suryawanshi, A. M. Syed, A. Ciling, M. McCavitt-Malvido, U. Schulze-Gahmen, J. Hayashi, I.-J. Kim, S. W. Fong, J. Batra, G. R. Kumar, , M. Ott

This study shows ORF8 suppresses viral particle production by interacting with Spike and causing Golgi fragmentation, supporting evolutionary pressure to delete ORF8 in SARS-CoV-2 variants.

bioRxiv · Mar 5, 2024 · PreprintMicrobiology

MuSK-BMP signaling in adult muscle stem cells maintains quiescence and regulates myofiber size

L. A. Madigan, D. Jaime, I. Chen, J. R. Fallon

This study shows that MuSK-BMP signaling regulates adult muscle stem cell quiescence and myofiber size, with reduced signaling increasing muscle size and function while preserving stemness.

bioRxiv · May 17, 2023 · PreprintCell Biology

Treatment of wound infections in a mouse model using Zn2+-releasing phage bound to gold nanorods

H. PENG, D. Rossetto, S. Mansy, M. Jordan, K. Roos, I. Chen

This study shows that phage-nanomaterial conjugates effectively treat P. aeruginosa infections in mice by reducing bacterial load and promoting wound healing without toxicity.

bioRxiv · Jan 5, 2022Bioengineering

Nurturing Diversity and Inclusion in AI in Biomedicine through a Virtual Summer Program for High School Students

T. Oskotsky, R. Bajaj, J. Burchard, T. B. Cavazos, I. Chen, W. Connell, S. Eaneff, T. Grant, I. Kanungo, K. Lindquist, D. J. Myers-Turnbull, Z. Z. C. Naing, A. Tang, B. Vora, J. X. Wang, , M. Sirota

The paper describes a virtual summer program for high school students aimed at increasing diversity in AI through biomedical education, showing improved knowledge and engagement in AI concepts.

bioRxiv · Mar 6, 2021Scientific Communication & Education

Glutamate transporters contain a conserved chloride channel with two hydrophobic gates

I. Chen, S. Pant, Q. Wu, R. Cater, M. Sobti, R. Vandenberg, A. G. Stewart, E. Tajkhorshid, J. Font, R. M. Ryan

The paper reports the cryo-EM structure of a glutamate transporter homologue, revealing a conserved chloride channel with two hydrophobic gates that facilitates dual-function transport.

Nature · Feb 17, 2021Peer-reviewedBiophysics