Author

T. Irie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 8 Organism:human· 8 Approach:experimental assay· 7 Assay:bulk RNA-seq· 1 Approach:comparative / phylogenetic analysis· 1 Organism:mouse· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

K. Uriu· 7 shared H. Nasser· 6 shared J. Ito· 6 shared T. Ikeda· 6 shared The Genotype to Phenotype Japan (G2P-Japan) Consortium· 6 shared A. Saito· 5 shared H. Asakura· 5 shared K. Sadamasu· 5 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

7 shared papersMicrobiology

K. Uriu

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Virological characteristics of the SARS-CoV-2 BA.2.86 variant

T. Tamura, K. Mizuma, H. Nasser, S. Deguchi, M. Padilla-Blanco, K. Uriu, J. E. M. Tolentino, S. Tsujino, R. Suzuki, I. Kojima, N. Nao, R. Shimizu, M. Jonathan, Y. Kosugi, Z. Guo, , K. Sato

This study investigates the virological characteristics of the SARS-CoV-2 BA.2.86 variant, finding it has higher reproduction number than EG.5.1 but lower pathogenicity and replication capacity compared to BA.2.

bioRxiv · Nov 2, 2023Microbiology

Virological characteristics of the SARS-CoV-2 Omicron EG.5.1 variant

S. Tsujino, S. Deguchi, T. Nomai, M. Padilla-Blanco, A. Plianchaisuk, L. Wang, M. M. Begum, K. Uriu, K. Mizuma, N. Nao, I. Kojima, T. Tsubo, J. Li, Y. Matsumura, M. Nagao, , Za

The paper investigates the virological features of the SARS-CoV-2 EG.5.1 variant, finding its fitness and antiviral sensitivity comparable to XBB.1.5, with structural differences in spike proteins.

bioRxiv · Oct 19, 2023Microbiology

Virological characteristics of the SARS-CoV-2 XBB.1.5 variant

T. Tamura, T. Irie, S. Deguchi, H. Yajima, M. Tsuda, H. Nasser, K. Mizuma, A. Plianchaisuk, S. Suzuki, K. Uriu, M. M. Begum, R. Shimizu, M. Jonathan, R. Suzuki, T. Kondo, , T. Fukuhara

The paper analyzes the virological characteristics of the SARS-CoV-2 XBB.1.5 variant, showing reduced pathogenicity and impaired MHC expression due to mutations in ORF8 and S.

bioRxiv · Aug 16, 2023 · PreprintMicrobiology

Optineurin deficiency impairs autophagy to cause interferon beta overproduction and increased survival of mice following viral infection

M. Fukushi, R. Ohsawa, Y. Okinaka, D. Oikawa, T. Kiyono, M. Moriwaki, T. Irie, K. Oda, Y. Kamei, F. Tokunaga, Y. Sotomaru, H. Maruyama, H. Kawakami, T. Sakaguchi

This study shows that optineurin deficiency leads to IFNβ overproduction and increased survival in mice during viral infection due to impaired autophagy.

bioRxiv · Mar 13, 2023 · PreprintImmunology

Virological characteristics of the SARS-CoV-2 Omicron BA.2.75

A. Saito, T. Tamura, J. Zahradnik, S. Deguchi, K. Tabata, I. Kimura, J. Ito, H. Nasser, M. Toyoda, K. Nagata, K. Uriu, Y. Kosugi, S. Fujita, D. Yamasoba, M. Shofa, , Kei Sato

This study investigates the virological characteristics of SARS-CoV-2 Omicron BA.2.75, finding it has higher transmissibility and pathogenicity compared to BA.2 and BA.5, but similar sensitivity to antiviral drugs.

bioRxiv · Jul 14, 2022Microbiology

SARS-CoV-2 spike S375F mutation characterizes the Omicron BA.1 variant

I. Kimura, D. Yamasoba, H. Nasser, J. Zahradnik, Y. Kosugi, J. Wu, K. Nagata, K. Uriu, Y. L. Tanaka, J. Ito, R. Shimizu, T. S. Tan, E. P. Butlertanaka, H. Asakura, K. Sadamasu, , K. Sato

This study identifies the S375F mutation in the Omicron spike protein as responsible for its reduced cleavage efficiency, fusogenicity, and rapid spread.

bioRxiv · Apr 3, 2022Microbiology

SARS-CoV-2 spike P681R mutation, a hallmark of the Delta variant, enhances viral fusogenicity and pathogenicity

A. Saito, T. Irie, R. Suzuki, T. Maemura, H. Nasser, K. Uriu, Y. Kosugi, K. Shirakawa, K. Sadamasu, I. Kimura, J. Ito, J. Wu, K. Iwatsuki-Horimoto, M. Ito, S. Yamayoshi, , K. Sato

This study shows the P681R mutation in the SARS-CoV-2 spike protein enhances fusogenicity and pathogenicity in the Delta variant compared to the prototypic virus.

bioRxiv · Jun 17, 2021Microbiology

SARS-CoV-2 ORF3b is a potent interferon antagonist whose activity is further increased by a naturally occurring elongation variant

Y. Konno, I. Kimura, K. Uriu, M. Fukushi, T. Irie, Y. Koyanagi, S. Nakagawa, K. Sato

This paper shows that SARS-CoV-2 ORF3b is a potent interferon antagonist, with a naturally occurring longer variant enhancing its anti-interferon activity in severe COVID-19 cases.

bioRxiv · May 11, 2020Microbiology