Author

Y. Kosugi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 20

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 20 Approach:experimental assay· 17 Organism:human· 16 Assay:proteomics· 5 Organism:virus· 4 Approach:comparative / phylogenetic analysis· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

The Genotype to Phenotype Japan (G2P-Japan) Consortium· 19 shared K. Sato· 17 shared K. Uriu· 17 shared J. Ito· 15 shared J. Zahradnik· 10 shared A. Saito· 9 shared H. Asakura· 9 shared I. Kimura· 9 shared

Activity by Year

2021-2023 · peak 10/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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19 shared papersMicrobiology

The Genotype to Phenotype Japan (G2P-Japan) Consortium

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Author profile →

20 papers

Recent·Most cited

Virological characteristics of the SARS-CoV-2 JN.1 variant

Y. Kaku, K. Okumura, M. Padilla-Blanco, Y. Kosugi, K. Uriu, A. A. Hinay, L. Chen, A. Plianchaisuk, K. Kobiyama, K. J. Ishii, The Genotype to Phenotype Japan (G2P-Japan) Consortium, J. Zahradnik, J. Ito, K. Sato

This study investigates the virological properties of the SARS-CoV-2 JN.1 variant, focusing on its mutations and potential immune evasion capabilities.

bioRxiv · Dec 8, 2023Microbiology

Antiviral humoral immunity against SARS-CoV-2 Omicron subvariants induced by XBB.1.5 monovalent vaccine in infection-naive and XBB-infected individuals

Y. Kosugi, Y. Kaku, A. A. Hinay, Z. Guo, K. Uriu, M. Kihara, F. Saito, Y. Uwamino, J. Kuramochi, K. Shirakawa, A. Takaori-Kondo, The Genotype to Phenotype Japan (G2P-Japan) Consortium, K. Sato

The paper assesses the humoral immune response to XBB.1.5 vaccine in infection-naive and XBB-infected individuals against various SARS-CoV-2 variants.

bioRxiv · Nov 29, 2023Microbiology

Virological characteristics of the SARS-CoV-2 Omicron HK.3 variant harboring the "FLip" substitution

Y. Kosugi, A. Plianchaisuk, O. Putri, K. Uriu, Y. Kaku, A. A. Hinay, L. Chen, J. Kuramochi, K. Sadamasu, K. Yoshimura, H. Asakura, M. Nagashima, The Genotype to Phenotype Japan (G2P-Japan) Consortium, J. Ito, K. Sato

This study investigates the virological properties of the SARS-CoV-2 HK.3 variant, a FLip variant with substitutions S:L455F and S:F456L, to assess its growth advantage.

bioRxiv · Nov 14, 2023 · PreprintMicrobiology

Virological characteristics of the SARS-CoV-2 BA.2.86 variant

T. Tamura, K. Mizuma, H. Nasser, S. Deguchi, M. Padilla-Blanco, K. Uriu, J. E. M. Tolentino, S. Tsujino, R. Suzuki, I. Kojima, N. Nao, R. Shimizu, M. Jonathan, Y. Kosugi, Z. Guo, , K. Sato

This study investigates the virological characteristics of the SARS-CoV-2 BA.2.86 variant, finding it has higher reproduction number than EG.5.1 but lower pathogenicity and replication capacity compared to BA.2.

bioRxiv · Nov 2, 2023Microbiology

NEDD4-binding protein 1 suppresses HBV replication by degrading HBV RNAs

N. Kobayashi, S. Suzuki, Y. Sakamoto, R. Suzuki, K. Mori, Y. Kosugi, L. Liang, T. Saito, T. Izumi, K. Noda, D. Okuzaki, Y. Kanegae, S. Hayashi, Y. Tanaka, Y. Matsuura, , T. Fukuhara

This paper identifies N4BP1 as a host factor that suppresses HBV replication by degrading HBV RNAs, with its KH-like and RNase domains required for this effect.

bioRxiv · Oct 6, 2023 · PreprintMicrobiology

Transmissibility, infectivity, and immune resistance of the SARS-CoV-2 BA.2.86 variant

K. Uriu, J. Ito, Y. Kosugi, Y. L. Tanaka, Y. Mugita, Z. Guo, A. A. Hinay, O. Putri, Y. Kim, R. Shimizu, M. M. Begum, M. Jonathan, The Genotype to Phenotype Japan (G2P-Japan) Consortium, A. Saito, T. Ikeda, K. Sato

This study investigates the transmissibility, infectivity, and immune resistance of the SARS-CoV-2 BA.2.86 variant, finding it to be highly immune evasive but with lower infectivity compared to other variants.

bioRxiv · Sep 7, 2023 · PreprintMicrobiology

Antiviral efficacy of the SARS-CoV-2 XBB breakthrough infection sera against Omicron subvariants including EG.5

Y. Kaku, Y. Kosugi, K. Uriu, J. Ito, J. Kuramochi, K. Sadamasu, K. Yoshimura, H. Asakura, M. Nagashima, The Genotype to Phenotype Japan (G2P-Japan) Consortium, K. Sato

This study evaluates the antiviral efficacy of XBB breakthrough infection sera against EG.5.1 and other Omicron subvariants, finding comparable neutralization titers and suggesting immune evasion is not the main driver of EG.5.1's spread.

bioRxiv · Aug 8, 2023 · PreprintMicrobiology

Virological characteristics of the SARS-CoV-2 Omicron XBB.1.16 variant

D. Yamasoba, K. Uriu, A. Plianchaisuk, Y. Kosugi, L. Pan, J. Zahradnik, The Genotype to Phenotype Japan (G2P-Japan) Consortium, J. Ito, K. Sato

This study characterizes the virological features of the SARS-CoV-2 Omicron XBB.1.16 variant, showing increased transmissibility and immune evasion compared to previous variants.

The Lancet Infectious Diseases · Jun 1, 2023Peer-reviewedMicrobiology

Determination of the factors responsible for host tropism of SARS-CoV-2-related bat coronaviruses

S. Fujita, Y. Kosugi, I. Kimura, K. Tokunaga, The Genotype to Phenotype Japan (G2P-Japan) Consortium, J. Ito, K. Sato

The paper identifies specific residues in the spike protein and ACE2 receptor that determine the host tropism of two SARS-CoV-2-related bat coronaviruses.

bioRxiv · Apr 13, 2023 · PreprintMicrobiology

Enhanced transmissibility, infectivity and immune resistance of the SARS-CoV-2 Omicron XBB.1.5 variant

K. Uriu, J. Ito, J. Zahradnik, S. Fujita, Y. Kosugi, G. Schreiber, The Genotype to Phenotype Japan (G2P-Japan) Consortium, K. Sato

This study evaluates the transmissibility, infectivity, and immune resistance of the SARS-CoV-2 Omicron XBB.1.5 variant, finding it more transmissible and resistant than previous variants.

bioRxiv · Jan 16, 2023Microbiology

Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants

T. Tamura, J. Ito, K. Uriu, J. Zahradnik, I. Kida, H. Nasser, M. Shofa, Y. Oda, S. Lytras, N. Nao, Y. Itakura, S. Deguchi, R. Suzuki, L. Wang, M. M. Begum, , K. Sato

This study identifies XBB as a SARS-CoV-2 variant resulting from recombination of BA.2 subvariants, showing increased resistance to neutralizing antibodies and enhanced fusogenicity compared to BA.2.75.

bioRxiv · Dec 27, 2022 · PreprintMicrobiology

Virological characteristics of the SARS-CoV-2 Omicron BA.2.75

A. Saito, T. Tamura, J. Zahradnik, S. Deguchi, K. Tabata, I. Kimura, J. Ito, H. Nasser, M. Toyoda, K. Nagata, K. Uriu, Y. Kosugi, S. Fujita, D. Yamasoba, M. Shofa, , Kei Sato

This study investigates the virological characteristics of SARS-CoV-2 Omicron BA.2.75, finding it has higher transmissibility and pathogenicity compared to BA.2 and BA.5, but similar sensitivity to antiviral drugs.

bioRxiv · Jul 14, 2022Microbiology

Virological characteristics of the novel SARS-CoV-2 Omicron variants including BA.2.12.1, BA.4 and BA.5

I. Kimura, D. Yamasoba, T. Tamura, N. Nao, Y. Oda, S. Mitoma, J. Ito, H. Nasser, J. Zahradnik, K. Uriu, S. Fujita, Y. Kosugi, L. Wang, M. Tsuda, M. Kishimoto, , K. Sato

This study analyzes the virological characteristics of SARS-CoV-2 Omicron variants BA.2.12.1, BA.4, and BA.5, finding they have higher reproduction numbers, reduced neutralization by prior immunity, increased replication in lung cells, and greater pathogenicity in hamsters compared to BA.2.

bioRxiv · May 26, 2022Microbiology

Sensitivity of novel SARS-CoV-2 Omicron subvariants, BA.2.11, BA.2.12.1, BA.4 and BA.5 to therapeutic monoclonal antibodies

D. Yamasoba, Y. Kosugi, I. Kimura, S. Fujita, K. Uriu, J. Ito, K. Sato, The Genotype to Phenotype Japan (G2P-Japan) Consortium

This study evaluates the sensitivity of new Omicron subvariants to eight therapeutic monoclonal antibodies, finding increased resistance in BA.4/5 to cilgavimab compared to BA.2.

bioRxiv · May 3, 2022Microbiology

SARS-CoV-2 spike S375F mutation characterizes the Omicron BA.1 variant

I. Kimura, D. Yamasoba, H. Nasser, J. Zahradnik, Y. Kosugi, J. Wu, K. Nagata, K. Uriu, Y. L. Tanaka, J. Ito, R. Shimizu, T. S. Tan, E. P. Butlertanaka, H. Asakura, K. Sadamasu, , K. Sato

This study identifies the S375F mutation in the Omicron spike protein as responsible for its reduced cleavage efficiency, fusogenicity, and rapid spread.

bioRxiv · Apr 3, 2022Microbiology

Virological characteristics of SARS-CoV-2 BA.2 variant

D. Yamasoba, I. Kimura, H. Nasser, Y. Morioka, N. Nao, J. Ito, K. Uriu, M. Tsuda, J. Zahradnik, K. Shirakawa, R. Suzuki, M. Kishimoto, Y. Kosugi, K. Kobiyama, T. Hara, , Sawa

This study compares the virological characteristics of SARS-CoV-2 BA.2 and BA.1 variants, finding BA.2 has higher transmissibility, different antigenicity, greater replicative capacity, and higher pathogenicity in hamsters.

bioRxiv · Feb 14, 2022Microbiology

Characterization of the immune resistance of SARS-CoV-2 Mu variant and the immunity induced by Mu infection

K. Uriu, P. Cardenas, E. Munoz, V. Barragan, Y. Kosugi, K. Shirakawa, A. Takaori-Kondo, Ecuador-COVID19 Consortium, The Genotype to Phenotype Japan (G2P-Japan) Consortium, K. Sato

This study identifies mutations in the SARS-CoV-2 Mu variant responsible for its immune resistance and shows that Mu-infected convalescent sera are broadly antiviral.

bioRxiv · Nov 23, 2021Microbiology

SARS-CoV-2 Lambda variant exhibits higher infectivity and immune resistance

I. Kimura, Y. Kosugi, J. Wu, D. Yamasoba, E. P. Butlertanaka, Y. L. Tanaka, Y. Liu, K. Shirakawa, Y. Kazuma, R. Nomura, Y. Horisawa, K. Tokunaga, A. Takaori-Kondo, H. Arase, The Genotype to Phenotype Japan (G2P-Japan) Consortium, , K. Sato

The paper investigates the SARS-CoV-2 Lambda variant, finding it more infectious due to specific mutations and better immune evasion, contributing to its spread in South America.

bioRxiv · Jul 28, 2021Microbiology

SARS-CoV-2 spike P681R mutation, a hallmark of the Delta variant, enhances viral fusogenicity and pathogenicity

A. Saito, T. Irie, R. Suzuki, T. Maemura, H. Nasser, K. Uriu, Y. Kosugi, K. Shirakawa, K. Sadamasu, I. Kimura, J. Ito, J. Wu, K. Iwatsuki-Horimoto, M. Ito, S. Yamayoshi, , K. Sato

This study shows the P681R mutation in the SARS-CoV-2 spike protein enhances fusogenicity and pathogenicity in the Delta variant compared to the prototypic virus.

bioRxiv · Jun 17, 2021Microbiology

An emerging SARS-CoV-2 mutant evading cellular immunity and increasing viral infectivity

C. Motozono, M. Toyoda, J. Zahradnik, T. Ikeda, A. Saito, T. S. Tan, I. Ngare, H. Nasser, I. Kimura, K. Uriu, Y. Kosugi, S. Torii, A. Yonekawa, N. Shimono, Y. Nagasaki, , K. Sato

This study identifies two SARS-CoV-2 mutations, L452R and Y453F, that evade HLA-restricted cellular immunity and increase viral infectivity.

bioRxiv · Apr 2, 2021Microbiology