Author

I. Sayed

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

S. Das· 3 shared A. Sharma· 2 shared D. Sahoo· 2 shared M. S. Anandachar· 2 shared P. Ghosh· 2 shared A. Ali· 1 shared A. Chakraborty· 1 shared A. Fonseca· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersImmunology

S. Das

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A Living Organoid Biobank of Crohn's Disease Patients Reveals Molecular Subtypes for Personalized Therapeutics

C. Tindle, G. Katkar, A. Fonseca, S. Taheri, J. Lee, P. Maity, I. Sayed, S.-R. Ibeawuchi, E. Vidales, R. Pranadinata, M. Fuller, D. Stec, M. S. Anandachar, K. Perry, H. Lee, , P. Ghosh

This paper creates a biobank of patient-derived organoids to identify molecular subtypes of Crohn's disease and test subtype-specific therapies.

bioRxiv · Mar 11, 2023Immunology

The crosstalk between microbial sensors ELMO1 and NOD2 shape intestinal immune responses

A. Sharma, S. Achi, S. R. Ibeawuchi, M. S. Anandachar, H. Gementera, U. Chaudhury, F. Usmani, K. Vega, I. Sayed, S. Das

This study shows that ELMO1 and NOD2 interact to control intestinal inflammation and bacterial clearance, with their dysfunction linked to Crohn's disease.

bioRxiv · Jul 9, 2022Microbiology

DNA glycosylase NEIL2 prevents Fusobacterium-mediated inflammation and DNA damage in colonic epithelial cells

I. Sayed, A. Chakraborty, A. Ali, A. Sharma, A. Sahan, D. Sahoo, P. Ghosh, T. Hazra, S. Das

This study shows that NEIL2, a DNA repair enzyme, is downregulated by Fusobacterium infection, leading to DNA damage and inflammation in colonic epithelial cells, and this effect is specific to microsatellite stable colorectal cancers.

bioRxiv · Jun 11, 2020Immunology