A. Fonseca

Quantitative RNA spatial profiling using single-molecule RNA FISH on plant tissue cryosections

This paper introduces an optimized smFISH protocol for plant tissue cryosections, enabling precise quantification of mRNA and validation of scRNA-seq data.

Differences in RAD51 transcriptional response and cell cycle dynamics reveal varying sensitivity to DNA damage among Arabidopsis thaliana root cell types

The paper examines RAD51 transcriptional response and cell cycle dynamics in Arabidopsis root cell types under DNA damage, revealing differences in sensitivity to genotoxic stress.

Regulatory T cells control type 1-driven immunopathology restraining GM-CSF-producing helper T cells

This study identifies GM-CSF-producing helper T cells as drivers of immunopathology, showing Treg cells restrain them to prevent tissue damage in mice.

A Living Organoid Biobank of Crohn's Disease Patients Reveals Molecular Subtypes for Personalized Therapeutics

This paper creates a biobank of patient-derived organoids to identify molecular subtypes of Crohn's disease and test subtype-specific therapies.

Whole-mount smFISH allows combining RNA and protein quantification at cellular and subcellular resolution

The paper introduces a method to quantify mRNA and protein at cellular and subcellular resolution in plants using whole-mount smFISH.

Adult Stem Cell-derived Complete Lung Organoid Models Emulate Lung Disease in COVID-19

This study develops a human lung organoid model to emulate COVID-19 pathogenesis, showing proximal airway cells drive viral infection while distal cells drive excessive immune response.

E-cigarettes compromise the gut barrier and trigger gut inflammation

This study shows that chronic e-cigarette use damages the gut barrier and causes inflammation, driven by non-nicotine chemicals in e-liquids.

Transcription factor TGA2 is essential for UV-B stress tolerance controlling oxidative stress in Arabidopsis

This study identifies TGA2 as essential for UV-B stress tolerance in Arabidopsis by activating antioxidant GSTU genes to control oxidative stress.

Postdoc X-ray in Europe 2017: work conditions, productivity, institutional support and career outlooks

This paper analyzes survey data on postdoctoral researchers in Europe, identifying issues like salary disparities, long working hours, and lack of institutional support, and recommends improvements to their career prospects.