M. Overholtzer

Tumorigenesis driven by the BRAF V600E oncoprotein requires secondary mutations that overcome its feedback inhibition of migration and invasion

This study shows that BRAFV600E mutations inhibit cell migration and invasion through feedback inhibition of RAC1, requiring secondary mutations to overcome this block and enable tumorigenesis.

WNK1 enforces macrophage lineage fidelity

This paper identifies WNK1 as essential for macrophage lineage fidelity, showing its role in preventing myeloid progenitors from differentiating into neutrophils.

The Genetic Basis of Transcriptional and Spatial Heterogeneity of Basal-Like Features in Pancreatic Ductal Adenocarcinoma

The paper identifies genetic and transcriptional features of basal-like subtypes in pancreatic ductal adenocarcinoma, linking them to squamous histology and chromatin modifier mutations.

Diverse roles of guanine nucleotide exchange factors in regulating collective cell migration

The paper identifies GEFs regulating collective cell migration by screening human bronchial epithelial cells, showing RHOA GEFs influence intercellular communication and motility.