Author

J. Ankarklev

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 5 Research Focus:gene regulatory network inference· 4 Organism:plant (other)· 3 Assay:scRNA-seq· 3 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2

Frequent Co-Authors

M. Mohammed· 4 shared A. Dziedziech· 3 shared J. Henriksson· 2 shared J. Vega-Rodriguez· 2 shared A. Barragan· 1 shared A. Bhandage· 1 shared A. Chan· 1 shared A. Jex· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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4 shared papersMicrobiology

M. Mohammed

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Single-cell sequencing of tumor-associated macrophages in a Drosophila model.

D. Khalili, M. Mohammed, M. Kunc, J. Ankarklev, U. Theopold

The paper uses a Drosophila model to study tumor-associated macrophages via single-cell RNA-sequencing, identifying distinct hemocyte clusters and their differential gene expression in tumor versus wild-type larvae.

bioRxiv · Jun 17, 2023 · PreprintCancer Biology

Amino acid usage and tRNA expression underlies proteome adaptation in Plasmodium falciparum

Q. Li, L. Vetter, Y. Veith, E. Christ, A. Vegvari, C. Sahin, U. Ribacke, M. Wahlgren, J. Ankarklev, O. Larsson, S. C. L. Chan

The paper shows that Plasmodium falciparum adjusts its tRNA profile and codon usage to adapt to amino acid availability from hemoglobin digestion, affecting protein synthesis and proliferation.

bioRxiv · Mar 20, 2023Microbiology

scDual-Seq of Toxoplasma gondii-infected mouse bone marrow-derived dendritic cells reveals host cell heterogeneity and differential infection dynamics

F. Hildebrandt, M. Mohammed, A. Dziedziech, A. Bhandage, A.-M. Divne, F. Barrenaes, A. Barragan, J. Henriksson, J. Ankarklev

The paper uses Dual-scSeq to analyze T. gondii-infected BMDCs, revealing differential infection dynamics and host-parasite gene interactions.

bioRxiv · Jan 13, 2023 · PreprintMicrobiology

Single-cell transcriptomics to define Plasmodium falciparum stage-transition in the mosquito midgut

M. Mohammed, A. Dziedziech, V. Sekar, M. Ernest, T. L. Alves E Silva, B. Balan, S. N. Emami, I. Biryukova, M. R. Friedlander, A. Jex, M. Jacobs-Lorena, J. Henriksson, J. Vega-Rodriguez, J. Ankarklev

This study uses single-cell transcriptomics to analyze Plasmodium falciparum development in the mosquito midgut, identifying transcriptional trajectories and stress responses, including genes encoding intrinsically disordered proteins.

bioRxiv · Apr 5, 2022Microbiology

Single-cell analysis of mosquito hemocytes identifies signatures of immune cell sub-types and cell differentiation

H. Kwon, M. Mohammed, O. Franzen, J. Ankarklev, R. C. Smith

The paper uses scRNA-seq to identify immune cell subtypes and differentiation in mosquitoes, defining markers and showing the role of lozenge in oenocytoid fate.

bioRxiv · Jul 11, 2020Immunology

A histone methyltransferase inhibitor can reverse epigenetically acquired drug resistance in the malaria parasite Plasmodium falciparum

A. Chan, A. Dziedziech, L. Kirkman, K. Deitsch, J. Ankarklev

This study shows that a histone methyltransferase inhibitor can reverse epigenetic drug resistance in Plasmodium falciparum by restoring clag3 gene expression and drug uptake.

bioRxiv · Sep 19, 2019Microbiology

Generation of Transgenic Human Malaria Parasites With Strong Fluorescence in the Transmission Stages

K. J. McLean, J. Straimer, C. S. Hopp, J. Vega-Rodriguez, A. Tripathi, G. Mlambo, P. C. Doumolin, C. T. Harris, X. Tong, M. J. Shears, J. Ankarklev, B. Kafsack, D. A. Fidock, P. Sinnis

The paper generates transgenic Plasmodium falciparum parasites with fluorescent transmission stages for improved study and screening.

bioRxiv · Dec 18, 2018 · PreprintMicrobiology