A. Chan

Dynamin-1 is a potential mediator in Cancer-Related Cognitive Impairment

This study investigates the role of Dynamin-1 in cancer-related cognitive impairment using human and animal models, finding that DNM1 downregulation is associated with cognitive impairment onset.

Development of BODIPY-based fluorescent probes for highly selective amino acid identification

This paper develops BODIPY-based fluorescent probes for selective amino acid identification through optimized spectral and photophysical properties.

Systematic Analysis of Immune Changes after B-cell Depletion in Autoimmune Multiple Sclerosis

This study uses single-cell RNA sequencing to analyze immune changes after B-cell depletion in MS patients, revealing cell type-specific effects on macrophages, monocytes, and T cells.

Piezo1 stretch-activated channel activity differs between bone marrow-derived and cardiac tissue-resident macrophages

This study compares stretch-activated channel activity in bone marrow-derived and cardiac tissue-resident macrophages, finding that Piezo1 activity is absent in the latter.

Dissecting components of the Campylobacter jejuni fetMP-fetABCDEF gene cluster in iron scavenging

This study investigates the role of the fetMP-fetABCDEF gene cluster in C. jejuni iron acquisition, showing that fetA-D are essential for growth under iron limitation and that FetE and FetF function redundantly as oxidoreductases.

Variation in temperature of peak trait performance will constrain adaptation of arthropod populations to climatic warming.

This study shows that arthropod adaptation to warming is constrained by trait performance temperature shifts and trade-offs, using a global dataset of 61 species.

The Alphaherpesvirus Latency Associated Promoter 2 (LAP2) Drives Strong Transgene Expression in Peripheral Tissue Depending on Administration Route and AAV Serotype

This study evaluates the effectiveness of the LAP2 promoter in AAV vectors for transgene expression in mouse tissues, showing it is as potent as EF1 but smaller, enabling larger payloads.

Pseudotyped Bat Coronavirus RaTG13 is efficiently neutralised by convalescent sera from SARS-CoV-2 infected Patients

This study shows that convalescent sera from SARS-CoV-2 infected patients efficiently neutralize RaTG13, a close coronavirus relative, more effectively than SARS-CoV-2 itself.

An immature subset of neuroblastoma cells synthesizes retinoic acid and depends on this metabolite

The paper identifies an immature neuroblastoma subset that synthesizes retinoic acid and is resistant to it, potentially contributing to therapy-resistant relapses.

The Ca2+-activated cation channel TRPM4 is a positive regulator of pressure overload-induced cardiac hypertrophy

This study identifies TRPM4 as a key regulator of pressure overload-induced cardiac hypertrophy by modulating CaMKII{delta}-HDAC4-MEF2A and calcineurin-NFAT-GATA4 pathways in mice.

How to build a water-splitting machine: structural insights into photosystem II assembly

The paper solves the structure of a PSII assembly intermediate using cryo-EM, revealing how assembly factors protect PSII during biogenesis and prepare it for water splitting.

Plasmacytoid dendritic cell expansion defines a distinct subset of RUNX1 mutated acute myeloid leukemia

This study identifies pDC-AML as a distinct AML subset with high RUNX1 mutations and pDC transcriptional features, suggesting CD123 targeting as a therapeutic strategy.

A histone methyltransferase inhibitor can reverse epigenetically acquired drug resistance in the malaria parasite Plasmodium falciparum

This study shows that a histone methyltransferase inhibitor can reverse epigenetic drug resistance in Plasmodium falciparum by restoring clag3 gene expression and drug uptake.

High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation

This study uses high-throughput phenotyping of knockout mice to identify genetic factors and structural patterns influencing immune variation.

Proximate causes and consequences of intergenerational influences of salient sensory experience.

This study shows that paternal exposure to salient sensory experiences can transmit effects to offspring via sperm RNA, influencing odor sensitivity and neuroanatomy in both sexes, and enhancing behavioral flexibility in females.