I. Fleming

Nuclear eNOS interacts with and S-nitrosates ADAR1 to modulate type I interferon signaling and endothelial function.

This study identifies nuclear eNOS's role in modulating ADAR1 activity and type I interferon signaling, linking NO bioavailability to endothelial function and atherogenesis.

Age-dependent RGS5 loss in pericytes induces cardiac dysfunction and fibrosis in the heart

This study shows that loss of RGS5 in pericytes with age leads to cardiac dysfunction and fibrosis by altering pericyte function and activating fibroblasts.

Early cellular and molecular signatures correlate with severity of West Nile Virus infection

The paper identifies cellular and molecular signatures associated with varying severities of West Nile Virus infection using multi-omics analysis of immune responses.

Inhibition of proline-rich-tyrosine kinase 2 restores cardioprotection by remote ischemic preconditioning in type 2 diabetes mellitus

This study shows that inhibiting Pyk2 restores cardioprotection lost in diabetes through improved endothelial function and eNOS activity during remote ischemic preconditioning.

Mena and VASP are required for vascular smooth muscle relaxation

This study shows that Mena and VASP are essential for vascular smooth muscle relaxation, with VASP deletion impairing relaxation responses to acetylcholine and nitric oxide.

Impaired H19 lncRNA expression contributes to the compromised developmental angiogenesis in EVL-deficient mice

The paper shows that reduced H19 lncRNA expression in EVL-deficient mice impairs VEGF expression and bioavailability, leading to compromised angiogenesis in the retina.

Ena/VASP proteins mediate endothelial cell repulsion from ephrin ligands

This study shows that Ena/VASP proteins are essential for endothelial cell repulsion from ephrin-B2 by mediating actin cytoskeleton collapse and Eph receptor signaling.

Impaired AMPK activity contributes to the inflammatory phenotype and the reduced phagocytosis capacity of VASP-deficient macrophages

This study shows that VASP deficiency reduces AMPK activity, leading to increased inflammation and impaired phagocytosis in macrophages.

Pro-inflammatory feedback loops define immune responses to pathogenic lentivirus infection

This study identifies pro-inflammatory feedback loops in immune responses to pathogenic lentivirus infection, showing that highly pathogenic variants induce delayed, sustained, and amplifying inflammatory circuits.

Epoxyeicosatrienoic acids and sEH inhibition prevent cardiac dysfunction in CVB3-induced myocarditis by positively regulating type I interferon signaling

This study shows that EETs and sEH inhibitors prevent CVB3-induced myocarditis by enhancing type I interferon signaling and improving viral resistance.

A novel role for cystathionine gamma lyase in the control of p53: impact on endothelial senescence and metabolic reprograming

This paper identifies CSE-p53 interaction as a regulator of endothelial cell senescence and metabolic reprogramming in aging, showing that restoring this interaction can prevent senescence and promote vascular repair.

Clinical implementation of single-cell RNA sequencing using liver fine needle aspirate tissue sampling and centralized processing captures compartment specific immuno-diversity

The paper develops a workflow for collecting and analyzing liver immune cells via fine-needle aspirates and single-cell RNA sequencing to better understand tissue-specific immunity in chronic hepatitis B.

Leukocyte dynamics after intracerebral hemorrhage in a living patient reveal rapid adaptations to tissue milieu

The paper uses single-cell RNA-sequencing to study leukocyte dynamics in a living patient after intracerebral hemorrhage, revealing rapid immune responses and adaptations to the hematoma microenvironment.