J. E. Parker

This study shows that helper NLR NRG1 forms oligomeric complexes with EDS1 and SAG101 at the plasma membrane upon co-activation of intracellular and cell surface receptors.

The paper shows TIR domains catalyze ADP-ribosylation reactions to produce signaling molecules that specifically activate the EDS1-SAG101-NRG1 immunity branch in plants.

The paper identifies TIR-catalyzed pRib-AMP/ADP as a signaling molecule in plant immunity and shows it binds to the EDS1-PAD4 complex.

The paper investigates the functional differences of EDS1 catalytic triad in Arabidopsis and Nicotiana benthamiana, finding lineage-specific roles in TNL immunity and PRR signaling.

The paper investigates whether XopQ-induced stromule formation is linked to ETI signaling or programmed cell death in N. benthamiana and finds it is connected to ETI signaling but not cell death.

The paper identifies four conserved TIR groups in land plants, two of which are EDS1-dependent and two are EDS1-independent in cell death activities.

The paper identifies a mutation in the ERG6 gene as the first mechanism of amphotericin B resistance in Candida auris, observed during in vivo treatment.

This study identifies TPR1's role in mitigating immune-related physiological damage in Arabidopsis by analyzing its chromatin binding and effects on gene expression and plant growth.

This study identifies SRF3 as a receptor kinase that coordinates iron homeostasis and immune responses in plants by regulating callose synthase activity.

This study shows that the fungal endophyte Serendipita vermifera synergizes with bacterial microbiota to protect Arabidopsis and barley from pathogens, with benefits dependent on host and microbiota composition.

The paper identifies two distinct modules, NRG1/EDS1/SAG101 and ADR1/EDS1/PAD4, required for TNL receptor immunity, showing effector recognition-dependent associations and functional requirements.

This study identifies the EDS1-PAD4-ADR1 node as a convergence point for immune signaling in Arabidopsis, linking surface and intracellular LRR receptors.

This study identifies a mechanism by which pattern recognition receptors (PRRs) in Arabidopsis thaliana confer salt tolerance through WRKY18/WRKY40 transcription factors.

The paper identifies HaRxL21, an oomycete effector, and shows it interacts with TPL to suppress plant immunity and promote pathogen susceptibility.

The paper identifies genome-wide chromatin binding sites of TPR1 in Arabidopsis using ChIP-seq and finds it binds genes involved in immunity and growth.

This study identifies a mutation in PAD4 that enhances resistance and cell death in Arabidopsis, revealing EDR1's role in regulating the EDS1-PAD4 complex to control defense responses.

The paper identifies UNE12 as a temperature-responsive regulator of salicylic acid immunity in Arabidopsis thaliana using natural variation and genetic analysis.

The paper shows that the N-terminal PAD4-lipase-like domain in Arabidopsis limits Green Peach Aphid infestation but not pathogen immunity, suggesting the C-terminal domain is needed for immune functions and EDS1 interaction.

The paper identifies a plant MLKL protein family structurally similar to vertebrate MLKL, which provides immunity against pathogens without inducing cell death.

The paper identifies a coevolved EDS1-SAG101-NRG1 module essential for TIR-domain immune receptor-mediated cell death signaling in plants.