Y. Che

Structure-Based Design of a Highly Immunogenic, Conformationally Stabilized FimH Antigen for a Urinary Tract Infection Vaccine

The paper designs a conformationally stabilized FimH antigen for a UTI vaccine, showing improved immunogenicity and structural similarity to native FimH.

Preclinical Characterization of the Omicron XBB.1.5-Adapted BNT162b2 COVID-19 Vaccine

The monovalent Omicron XBB.1.5-adapted BNT162b2 mRNA vaccine elicits stronger neutralizing antibody responses against XBB.1.5 and related sublineages than the bivalent Wild Type + Omicron BA.4/5 vaccine.

Artificially cultivated duckweed: a high-efficiency starch producer

This paper reports a method to produce starch efficiently from duckweed under specific conditions and identifies mechanisms behind its high starch accumulation.

Duckweed evolution: from land back to water

This study investigates the reverse evolution of duckweed from land back to water, showing gradual degeneration in root structure, stomatal function, and lignocellulose content, along with gene pathway changes.

Enterobacteriaceae isolated from patients share antibiotic resistance conferring plasmids recently acquired from those isolated from sinks in the same treatment room

The paper identifies shared antibiotic resistance plasmids between patient and sink isolates, suggesting plasmid transmission from sinks to patients.

Engineering bacterial blight-resistant plants through CRISPR/Cas9-targeted editing of the MeSWEET10a promoter in cassava

This study edits the MeSWEET10a promoter in cassava to confer resistance to bacterial blight without affecting yield traits.

Bile Acid Restrained T Cell Activation Explains Cholestasis Aggravated Hepatitis B Virus Infection

This study shows that bile acids impair CD4+ T cell activation in cholestasis, worsening HBV infection outcomes by disrupting calcium signaling and metabolic reprogramming.

Reactivities of the Front Pocket N-Cap Cysteines in Human Kinases

This study uses CpHMD simulations to analyze cysteine reactivity in kinase N-cap positions, finding that some are reactive while others are not, depending on nearby residues.

Coral symbionts exhibit a polycistronic flavodiiron gene leading to functional proteins in photosynthesis

The paper identifies a polycistronic FLV gene in coral symbionts that produces functional proteins involved in photosynthesis, differing from the typical gene pair structure in other organisms.

BNT162b vaccines are immunogenic and protect non-human primates against SARS-CoV-2

This paper evaluates two BNT162b vaccine candidates in non-human primates, showing they are immunogenic and protect against SARS-CoV-2 infection.

Mitochondria fragment and reassemble to initiate the formation and development of the nucleus

The paper shows mitochondria fragment and reassemble to form nuclei and intranuclear inclusions during nuclear development.

A prefusion SARS-CoV-2 spike RNA vaccine is highly immunogenic and prevents lung infection in non-human primates

This paper reports on a prefusion SARS-CoV-2 spike RNA vaccine that induces strong immune responses and prevents lung infection in non-human primates.

A valid protective immune response elicited in rhesus macaques by an inactivated vaccine is capable of defending against SARS-CoV-2 infection

This study shows an inactivated SARS-CoV-2 vaccine induces neutralizing antibodies and CTL responses in rhesus macaques, effectively preventing viral replication and lung inflammation.

Machine Learning for Prioritization of Thermostabilizing Mutations for G-protein Coupled Receptors

The paper develops a machine learning framework to predict thermostable mutations for GPCRs, achieving higher success rates than systematic alanine scanning.

Structural basis for the transport mechanism of the human glutamine transporter SLC1A5 (ASCT2)

This study presents cryo-EM structures of the human glutamine transporter SLC1A5 in an outward-facing conformation, revealing insights into its transport mechanism and substrate recognition.

Hv1 channel supports insulin secretion in pancreatic β cells through calcium entry, depolarization and intracellular pH regulation