S. Jena

Detailed Survey of an in-vitro Intestinal Epithelium Model by Single-Cell Transcriptomics

This study uses single-cell RNA sequencing to analyze a Caco-2/HT29 co-culture model, identifying cell types and assessing its similarity to human intestinal epithelium, finding it lacks some transporters and immune markers.

Simplicity: web-based visualization and analysis of high-throughput cancer cell line screens

Simplicity provides a web-based tool for visualizing and analyzing high-throughput cancer cell line screens, enabling recalculation of summary statistics at user-defined drug concentrations.

Metformin impairs trophoblast metabolism and differentiation in dose dependent manner

This study shows that high-dose metformin impairs trophoblast metabolism and differentiation, while therapeutic doses do not.

Transgenic Mouse Models Establish a Protective Role of Type 1 IFN Response in SARS-CoV-2 infection-related Immunopathology

This study uses transgenic mouse models to show that a heightened type 1 IFN response protects against SARS-CoV-2-induced immunopathology, with Irgm1 as a potential therapeutic target.

Biosynthetic heme of malaria parasite induces cerebral pathogenesis by regulating hemozoin formation and griseofulvin can prevent cerebral malaria

The paper shows biosynthetic heme in malaria parasites promotes cerebral pathogenesis by enhancing hemozoin formation, and griseofulvin prevents cerebral malaria by targeting heme synthesis.

Identification and characterization of novel plasma proteins in drug resistant HIV/AIDS patients by SWATH-MS

This study identifies and characterizes novel plasma proteins differentially expressed in drug-resistant HIV/AIDS patients using SWATH-MS.

Comparative evaluation of plasma protein purification and 2-D gel electrophoresis protocols for analysis of HIV-1 infected human plasma proteins

The paper evaluates plasma protein purification protocols for HIV-1 infected human plasma, finding that the Aurum serum mini kit provides better resolution of low-abundance proteins in 2-D gel electrophoresis.

A self-exciting point process to study multi-cellular spatial signaling patterns

This paper introduces a spatiotemporal model of dynamic cell signaling using Hawkes processes to capture both single-cell and spatial signaling behaviors in multi-cellular systems.

Does plant root architecture respond to potassium nutrition under water stress? A case from rice seedling root responses.

This study investigates how potassium nutrition affects rice seedling root architecture under water stress and finds that K availability influences root morphology but not necessarily growth under severe stress.

Multiplexable fluorescence lifetime imaging (FLIM) probes for Abl and Src-family kinases

The paper develops and applies FLIM probes to measure Abl and Src-family kinase activities in live cells without FRET or genetic encoding.

A live-cell screen for altered Erk dynamics reveals principles of proliferative control

The paper performs a live-cell screen of kinase inhibitors to identify modulators of Erk dynamics and shows how these dynamics affect cell proliferation.