J. T. Smith

Fluorescence Lifetime Imaging for Quantification of Targeted Drug Delivery in Varying Tumor Microenvironments

This study uses fluorescence lifetime imaging to quantify TZM-HER2 binding and distribution in tumors with varying microenvironments, showing differences in drug delivery efficacy between cancer types.

A Novel Milli-fluidic Liver Tissue Chip with continuous Recirculation for Predictive pharmacokinetics Applications

This paper develops a milli-fluidic liver tissue chip with continuous recirculation to improve predictive pharmacokinetics by enhancing physiological relevance and long-term culture stability.

The carbapenem inoculum effect provides insight into the molecular mechanisms underlying carbapenem resistance in the Enterobacterales

This study shows that carbapenemase-producing CRE exhibit an inoculum effect, which can mislead susceptibility testing and highlights the need for improved detection methods.

Translational control by Trypanosoma brucei DRBD18 contributes to the maintenance of the procyclic state

This study shows that DRBD18 in Trypanosoma brucei regulates translational efficiency of specific transcripts, maintaining the procyclic form by repressing procyclic-specific proteins and enhancing bloodstream/metacyclic-specific proteins.

in vivo quantitative FRET small animal imaging: intensity versus lifetime-based FRET

This paper compares intensity-based and fluorescence lifetime-based FRET methods for in vivo small animal imaging, showing that lifetime-based FRET is more efficient and accurate for quantifying drug-target engagement.

Mapping Tree Cover Expansion in Montana, U.S.A. Rangelands using High-Resolution Historical Aerial Imagery

The paper estimates conifer tree cover expansion in Montana rangelands using historical and modern aerial imagery with a convolutional neural network, finding 3.0 million hectares of expansion.

Unannotated small RNA clusters in circulating extracellular vesicles detect early stage liver cancer

The paper identifies a 3-smRC signature from circulating extracellular vesicles that detects early-stage liver cancer with high sensitivity and specificity.

Regional context for balancing sagebrush- and woodland-dependent songbird needs with targeted pinyon-juniper management in the sagebrush biome

The paper models habitat use for sagebrush- and pinyon-juniper-dependent songbirds to show that sage grouse restoration can coexist with pinyon jay protection through targeted conifer management.

In vitro and in vivo NIR Fluorescence Lifetime Imaging with a time-gated SPAD camera

This study demonstrates the use of a time-gated SPAD camera for in vitro and in vivo NIR fluorescence lifetime imaging, showing its effectiveness in monitoring molecular events in tumor xenografts.

Where there's smoke, there's fuel: dynamic vegetation data improve predictions of wildfire hazard in the Great Basin

This study uses dynamic vegetation data and machine learning to predict wildfire hazard in the Great Basin, finding that fire probability is strongly linked to vegetation biomass, bare ground cover, and drought indices.

The elevational ascent and spread of exotic annual grass dominance in the Great Basin, USA

The paper quantifies the rapid expansion of exotic annual grass dominance in the Great Basin, showing an eight-fold increase in area and spread into higher elevations and north-facing slopes.

Spectral and lifetime fluorescence unmixing via deep learning

This paper introduces UNMIX-ME, a deep learning method for fluorescence unmixing that combines spectral and temporal data to improve quantification of fluorescent species in biological samples.

Ultra-fast fit-free analysis of complex fluorescence lifetime imaging via deep learning

This paper introduces FLI-Net, a deep learning model that enables ultra-fast, fit-free analysis of fluorescence lifetime imaging data across multiple spectral ranges and acquisition technologies.