M. J. Moore

Structural insights into CXCR4 modulation and oligomerization

This study uses cryoEM to reveal structural details of CXCR4 activation by CXCL12 and its oligomerization, showing new modes of GPCR regulation.

Functional mRNA delivery to hematopoietic stem and progenitor cells in vivo.

This study demonstrates in vivo delivery of functional mRNA to hematopoietic stem cells (HSC) using lipid nanoparticles, achieving transfection in ~25% of mouse HSC with potential for therapeutic applications.

Structural analysis of cancer-relevant TCR-CD3 and peptide-MHC complexes by cryoEM

The paper reports cryoEM structures of TCR-CD3 complexes and pMHC ligands, revealing structural insights into TCR recognition of cancer antigens.

Target enrichment and extensive population sampling help untangle the recent, rapid radiation of Oenothera sect. Calylophus

This study uses target enrichment and dense sampling to clarify the phylogeny and evolutionary history of Oenothera sect. Calylophus, revealing multiple origins of key traits.

A phylogenomic perspective on gene tree conflict and character evolution in Caprifoliaceae using target enrichment data, with Zabelioideae recognized as a new subfamily

This study uses target enrichment data to analyze phylogenetic conflicts in Caprifoliaceae, identifying ancient hybridization as a main source of discordance and recognizing Zabelioideae as a new subfamily.

Free circular introns with an unusual branchpoint in neuronal projections

The paper identifies free circular introns with an unusual branchpoint enriched in neuronal projections from rat hippocampal neurons.

Human Nerve-on-a-Chip. Engineering 3D functional human peripheral nerve in vitro

The paper develops a human peripheral nerve-on-a-chip system that enables neurite outgrowth, myelination, and nerve conduction velocity evaluation in vitro.

Evolution of Portulacineae marked by gene tree conflict and gene family expansion associated with adaptation to harsh environments

This study reconstructs the phylogeny of Portulacineae and examines molecular evolution correlates with adaptation to harsh environments, identifying gene duplications and expansions linked to stress responses.

Single-molecule FISH in Drosophila muscle reveals location dependent mRNA composition of megaRNPs

The paper develops a method to accurately localize mRNA in thick Drosophila muscle tissues using optimized smFISH and 3D segmentation.

Widespread paleopolyploidy, gene tree conflict, and recalcitrant relationships among the carnivorous Caryophyllales

The paper uses phylogenomic data to analyze relationships among carnivorous Caryophyllales, finding gene tree conflict, paleopolyploidy events, and unresolved relationships.