Myeloid-mesenchymal crosstalk drives Arg1-dependent profibrotic metabolism via ornithine in lung fibrosis
P. Yadav, J. Gomez Ortega, P. Dabral, W. Tamaki, C. Chien, K.-C. Chang, N. Biswas, S. Pan, J. Nilsson, X. Yin, A. Bhattacharyya, K. Boostanpour, T. Jujaray, J. Wang, T. Tsukui, , M. Bhattacharya
The paper identifies a myeloid-mesenchymal crosstalk pathway involving Arg1 and ornithine that drives profibrotic metabolism in lung fibrosis.
bioRxiv · Sep 6, 2023Immunology