Author

K. L. Lynch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

R. Thomas· 2 shared A. Andrew· 1 shared A. Arkal· 1 shared A. Byrne· 1 shared A. Gervais· 1 shared A. J. Combes· 1 shared A. Ogorodnikov· 1 shared A. R. Pico· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersImmunology

R. Thomas

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Long COVID manifests with T cell dysregulation, inflammation, and an uncoordinated adaptive immune response to SARS-CoV-2

K. Yin, M. J. Peluso, X. Luo, R. Thomas, M.-G. Shin, J. Neidleman, A. Andrew, K. Young, T. Ma, R. Hoh, K. Anglin, B. Huang, U. Argueta, M. Lopez, D. Valdivieso, , N. R. Roan

This study identifies T cell dysregulation, inflammation, and mis-coordinated adaptive immune responses in Long COVID patients compared to non-LC individuals.

bioRxiv · Feb 9, 2023Immunology

SARS-CoV-2 spike protein induces abnormal inflammatory blood clots neutralized by fibrin immunotherapy

J. K. Ryu, E. G. Sozmen, K. Dixit, M. Montano, Y. Matsui, Y. Liu, E. Helmy, T. J. Deerinck, Z. Yan, R. Schuck, R. M. Acevedo, C. M. Spencer, R. Thomas, A. R. Pico, S. S. Zamvil, , K. Akassoglou

This study shows SARS-CoV-2 Spike protein causes abnormal blood clots and thromboinflammation, which are neutralized by a fibrin-targeting antibody.

bioRxiv · Oct 12, 2021 · PreprintImmunology

Longitudinal single-cell epitope and RNA-sequencing reveals the immunological impact of type 1 interferon autoantibodies in critical COVID-19

M. G. P. van der Wijst, S. E. Vazquez, G. C. Hartoularos, P. Bastard, T. Grant, R. Bueno, D. S. Lee, J. R. Greenland, Y. Sun, R. Perez, A. Ogorodnikov, A. Ward, S. A. Mann, K. L. Lynch, C. Yun, , C. R. Langelier

The paper examines IFN-I autoantibodies in critical COVID-19 patients through longitudinal single-cell analysis, revealing suppressed ISG-I responses in myeloid cells.

bioRxiv · Mar 9, 2021 · PreprintImmunology

A viral histone-like protein exploits antagonism between linker histones and HMGB proteins to obstruct the cell cycle

K. L. Lynch, M. Bat-Erdene, M. R. Dillon, H. C. Lewis, D. C. Avgousti

This study shows adenovirus protein VII disrupts the H1-HMGB balance to block the cell cycle, ensuring resources for viral replication.

bioRxiv · Dec 11, 2020Microbiology