K. Nagashima

Strain dropouts reveal interactions that govern the metabolic output of the gut microbiome

The paper investigates how strain dropouts in the gut microbiome affect community metabolism and host physiology, finding that functionally redundant strains can have significant impacts outside their niche.

Mapping the T cell repertoire to a complex gut bacterial community

The paper maps T cell responses to a complex gut bacterial community and identifies a conserved antigen recognized by multiple TCRs.

Endosomes deliver ceramide phosphoethanolamine with unique acyl chain anchors to the cleavage furrow during male meiotic cytokinesis

The paper was withdrawn due to duplicate posting, and the correct version is available at the provided URL.

Differential recognition of computationally optimized H3 hemagglutinin influenza vaccine candidates by human antibodies

This study evaluates the antigenic and structural features of computationally optimized H3 HA influenza vaccine candidates, showing that TJ5 and J4 are better recognized by human B cells and mAbs than NG2 and a wild-type HA.

The pre-existing human antibody repertoire to computationally optimized influenza H1 hemagglutinin vaccines

This study identifies pre-existing human B cell responses to computationally optimized H1 hemagglutinin vaccines, showing cross-reactivity and functional antibodies targeting head, central stalk, and anchor epitopes.

In vivo augmentation of a complex gut bacterial community

The paper improves a synthetic gut microbiota community by adding strains that persist after fecal challenge and removing those that do not, resulting in a more stable model of the human gut microbiome.

Endosomes deliver ceramide phosphoethanolamine with unique acyl chain anchors to the cleavage furrow during male meiotic cytokinesis

This study identifies Ceramide phosphoethanolamine (CPE) and its delivery via Rab7-positive endosomes as essential for male meiotic cytokinesis.

Eliciting a potent antitumor immune response by expressing tumor antigens in a skin commensal

This paper shows that expressing tumor antigens in skin commensal bacteria can elicit a potent antitumor immune response without causing autoimmunity.