S. Ram

Global survey of secondary metabolism in Aspergillus niger via activation of specific transcription factors

The paper identifies novel secondary metabolites in Aspergillus niger by overexpressing transcription factors linked to cryptic biosynthetic gene clusters.

The long non-coding RNA NEAT1 regulates the transcriptional landscape of cardiomyocytes

This study identifies NEAT1 as a calcium-regulated lncRNA that promotes cardiac hypertrophy by modulating GRK2 expression and transcriptional regulation in cardiomyocytes.

Gardnerella vaginolysin potentiates glycan molecular mimicry by Neisseria gonorrhoeae

This study shows that Gardnerella vaginolysin releases host cell contents that enhance Neisseria gonorrhoeae's ability to mimic host glycans and evade immune detection.

Bacterial cell widening alters periplasmic size and activates envelope stress responses

This study shows that changes in bacterial cell width affect periplasmic thickness and activate the Rcs stress response system through RcsF.

Gramicidin S and Melittin - Potential anti-viral therapeutic peptides to treat SARS-CoV-2 infection

This study evaluates gramicidin S and melittin as potential anti-SARS-CoV-2 agents, showing reduced viral load and cytotoxicity in vitro with significant protein regulation.

Dry Swab Method of sample collection for SARS-CoV2 testing can be used for culturing virus

This study shows that SARS-CoV-2 can be cultured from dry swabs stored at room temperature or 4°C, comparable to traditional viral transport medium.

Host tropism determination by convergent evolution of immunological evasion in the Lyme disease system

The paper identifies CspA as a determinant of host tropism in Lyme disease bacteria, showing convergent evolution drives transmission differences among vertebrates.

Pixelwise H-score: a novel digital image analysis based-metric to quantify membrane biomarker expression from immunohistochemistry images

This paper introduces a new digital image analysis metric, the pixelwise H-score, to quantify membrane biomarker expression in IHC images, showing it is comparable or better than existing methods.

Characterizing intra-tumor and inter-tumor variability of immune cell infiltrates in murine syngeneic tumors

The paper analyzes immune cell variability in murine tumors using IHC and DIA, showing inter-tumor variation dominates and reveals compositional heterogeneity.

Information theoretic analysis of hyperspectralimaging systems with applications to fluorescencemicroscopy

The paper develops a stochastic model for hyperspectral imaging and analyzes spectral resolution limits in fluorescence microscopy using Fisher information and performance bounds.

A novel sialylation site on Neisseria gonorrhoeae lipooligosaccharide links heptose II lactose expression with pathogenicity

This paper identifies a novel sialylation site on Neisseria gonorrhoeae lipooligosaccharide that links HepII lactose expression with pathogenicity and vaccine potential.

Intensity-based axial localization approaches for multifocal plane microscopy

This paper evaluates intensity-based axial localization methods for multifocal plane microscopy and introduces a new non-parametric method, MILA, which improves robustness against sub-pixel location biases.