Author

L. Dagley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Organism:Drosophila· 1

Frequent Co-Authors

A. I. Webb· 2 shared A. J. Kueh· 1 shared A. M. Lew· 1 shared A. Seidi· 1 shared A. Vince· 1 shared A. Webb· 1 shared C. J. Tonkin· 1 shared D. Frank· 1 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBiochemistry

A. I. Webb

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

CIS calibrates GM-CSF signalling strength to regulate macrophage polarization via a STAT5-IRF8 axis

s. zhang, J. Rautela, N. G. Bediaga, T. Kolesnik, Y. You, L. Dagley, J. Bedo, H. Wang, L. Sun, R. Sutherland, E. Surgenor, N. Iannarella, R. S. Allan, F. Souza-Fonseca-Guimaraes, Y. Xie, , Y. Zhan

This study identifies CIS as a regulator of GM-CSF signaling that controls macrophage polarization via the STAT5-IRF8 axis, influencing immune responses and allergic inflammation.

bioRxiv · Mar 31, 2022 · PreprintImmunology

Simplified high-throughput methods for deep proteome analysis on the timsTOF Pro

J. J. Sandow, G. Infusini, L. Dagley, R. Larsen, A. I. Webb

The paper describes simplified high-throughput methods for deep proteome analysis using the timsTOF Pro instrument, achieving high protein identifications with short separation gradients.

bioRxiv · Apr 7, 2021 · PreprintBiochemistry

The inflammasome-activated cytokine IL-1 is targeted for ubiquitylation and proteasomal degradation to limit its inflammatory potential

S. Vijayaraj, R. Feltham, M. Rashidi, D. Frank, Z. Liu, D. Simpson, G. Ebert, A. Vince, M. J. Herold, A. J. Kueh, J. Pearson, L. Dagley, J. M. Murphy, A. I. Webb, K. E. Lawlor, J. E. Vince

This study shows that IL-1β is ubiquitylated and degraded to limit its inflammatory activity, with specific ubiquitin modifications and electrostatic interactions playing key roles.

bioRxiv · Mar 15, 2021 · PreprintImmunology

Identification of a divergent cytochrome c oxidase complex in the mitochondrial proteome of Toxoplasma gondii

A. Seidi, L. S. Muellner-Wong, E. Rajendran, E. T. Tjhin, L. Dagley, V. Y. T. Aw, A. Webb, C. J. Tonkin, G. van Dooren

The paper identifies a divergent cytochrome c oxidase complex in Toxoplasma gondii mitochondria, revealing unique proteins essential for parasite survival.

bioRxiv · May 11, 2018Microbiology