Y. Zhan

Aging limits stemness and tumorigenesis in the lung by reprogramming iron homeostasis

This study shows aging reduces lung stem cell function and suppresses lung cancer by inducing iron deficiency through the NUPR1-lipocalin-2 pathway.

Three-step mechanism of promoter escape by RNA polymerase II

The paper identifies a three-step mechanism for RNA polymerase II promoter escape using in vitro reconstitution and structural analysis.

Tumor Stroma Content Regulates Penetration and Efficacy of Tumor-targeting Bacteria

This study shows that high collagen content in tumors limits bacterial penetration and reduces the efficacy of Salmonella-based cancer therapy.

Chromosome-level Subgenome-aware de novo Assembly of Saccharomyces bayanus Provides Insight into Genome Divergence after Hybridization

This study assembles the chromosome-level genome of Saccharomyces bayanus and compares it to its parental species to understand genome divergence after hybridization.

Robust Neutralization of SARS-CoV-2 Variants Including JN.1 and BA.2.87.1 by Trivalent XBB Vaccine-Induced Antibodies

The paper compares antibody responses from individuals with XBB reinfection and those vaccinated with WSK-V102C, showing the vaccine induces stronger neutralization against SARS-CoV-2 variants including JN.1 and BA.2.87.1.

Integrated Hfq-interacting RNAome and transcriptomic analysis reveals complex regulatory networks of nitrogen fixation in root-associated Pseudomonas stutzeri A1501

This study identifies Hfq-binding RNAs in Pseudomonas stutzeri A1501 using eCLIP-seq, revealing new regulatory targets involved in nitrogen fixation and other metabolic processes.

Enhancer-driven local 3D chromatin domain folding modulates transcription in human mammary tumor cells

The paper investigates how enhancer-driven 3D chromatin domain folding regulates transcription in human mammary tumor cells following estradiol stimulation.

A senescence-like state is beneficial for ovarian cancer treatment

This study shows that senescence in ovarian cancer cells after chemotherapy correlates with better patient survival, suggesting senescence could be a therapeutic target.

Co-engagement of TIGIT+ immune cells to PD-L1+ tumours by a bispecific antibody potentiates T-cell response and tumour control

This paper shows that a bispecific antibody targeting PD-L1 and TIGIT enhances T-cell response and tumor control compared to using the individual antibodies.

Targeting Sex Determination to Suppress Mosquito Populations

This paper develops a CRISPR-based sterile insect technique to suppress Aedes aegypti populations by generating sterile males that outcompete wild mosquitoes.

Fingerprint SRS Imaging Unveils Ergosteryl Ester as a Metabolic Signature of Azole-Resistant Candida albicans

This paper identifies ergosteryl ester accumulation as a metabolic signature of azole-resistant Candida albicans using fingerprint SRS imaging and demonstrates a dual therapeutic strategy to suppress its viability.

O-GlcNAcylation promotes YTHDF1 cytosolic localization and colorectal cancer tumorigenesis

This study shows O-GlcNAcylation of YTHDF1 enhances its cytosolic localization and promotes colorectal cancer by increasing c-Myc expression.

An integrated approach to study chromatin and transcriptional dynamics throughout the cell cycle without pharmacological inhibition

The paper compares chromatin and transcriptional dynamics across cell cycle phases in mESCs using different synchronization methods, finding that CDK1 inhibitor synchronization best mimics G2/M phase.

CIS calibrates GM-CSF signalling strength to regulate macrophage polarization via a STAT5-IRF8 axis

This study identifies CIS as a regulator of GM-CSF signaling that controls macrophage polarization via the STAT5-IRF8 axis, influencing immune responses and allergic inflammation.

Harringtonine has the effects of double blocking SARS-CoV-2 membrane fusion

This study shows Harringtonine inhibits SARS-CoV-2 membrane fusion by targeting both the viral S protein and host TMPRSS2, effectively blocking infection in delta and Omicron variants.

Encoding sensing functions into material interface for a rationally engineered integrated electrochemical liquid biopsy

This paper develops an integrated electrochemical liquid biopsy platform for detecting cancer exosomes from blood using a rational engineering strategy.

Photoinactivation of catalase sensitizes Candida albicans and Candida auris to ROS-producing agents and immune cells

This study shows that photoinactivating catalase in fungi makes them more susceptible to ROS and immune cells, offering a new approach to treat drug-resistant fungal infections.

Photoinactivation of Catalase Sensitizes Wide-Ranging Bacteria to ROS-Producing Agents and Immune Cells

This study shows that blue light inactivates catalase in bacteria, making them vulnerable to ROS and immune cells, and validates this in a mouse model.

Pharmacologic inhibition of Protein Kinase C α and Protein Kinase C β halts renal function decline indirectly, by blunting hyperphagia, and directly reduces adiposity in the ZSF1 rat model of type 2 diabetes

The paper evaluates a PKC inhibitor in a T2D rat model, finding it halts renal decline indirectly via reduced hyperphagia and directly lowers adiposity.

Bifractal nature of chromosome contact maps

This paper analyzes Hi-C contact maps using multifractal analysis, revealing bifractal properties and detecting conformational changes in human stem cell differentiation.

An Engineered Genetic Circuit for Lactose Intolerance Alleviation Coupled with Gut Microbiota Recovery

This paper presents a genetic circuit that alleviates lactose intolerance by boosting beta-galactosidase activity and restoring gut microbiota through pH regulation in mice.

The pleiotropic effects of the MNK1/2-eIF4E axis support immune suppression and metastasis in a model of postpartum breast cancer.

This study shows that the MNK1/2-eIF4E axis promotes immune suppression and metastasis in postpartum breast cancer by affecting both tumor and non-tumor cells.

Chloroquine and hydroxychloroquine as ACE2 blockers to inhibit viropexis of 2019-nCoV Spike pseudotyped virus

This study investigates whether chloroquine and hydroxychloroquine inhibit 2019-nCoV infection by blocking ACE2 binding, showing both drugs suppress virus entry into ACE2-expressing cells.

The MNK1/2-eIF4E axis contributes to phenotype switching, melanoma progression, and resistance to immunotherapy.

This study identifies the MNK1/2-eIF4E axis as a driver of melanoma phenotype switching, progression, and immunotherapy resistance, with potential therapeutic targeting.

Effect of Assembly Method on Nanoparticle Attachment Density, Growth Rate, and Motility of Nanoscale Bacteria Enabled Autonomous Drug Delivery System (NanoBEADS)

The paper investigates how assembly methods affect nanoparticle attachment, growth, and motility in NanoBEADS for drug delivery.

Multistep metabolic engineering of Bacillus licheniformis to improve pulcherriminic acid production

This paper improves pulcherriminic acid production in Bacillus licheniformis through multistep metabolic engineering, achieving a record yield of 556.1 mg/L.

Photo-Disassembly of Membrane Microdomains Revives Conventional Antibiotics against MRSA

This study uses photo-disassembly of membrane microdomains to restore antibiotic susceptibility in MRSA, enabling conventional antibiotics to inhibit resistance development.

Parallel Concerted Evolution of Ribosomal Protein Genes in Fungi and Its Adaptive Significance

This study investigates the duplication and maintenance of ribosomal protein genes in fungi, finding parallel concerted evolution and adaptive advantages in sugar-rich environments.

Cellular senescence is a central response to cytotoxic chemotherapy in high-grade serous ovarian cancer

The paper shows that chemotherapy induces cellular senescence in high-grade serous ovarian cancer, which correlates with better patient survival.