Author

L. Gapin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5

Signature Assays, Organisms & Methods

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Organism:mouse· 5 Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Assay:scRNA-seq· 3 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

L. Loh· 3 shared A. Spengler· 2 shared J. Domenico· 2 shared J. Scott-Browne· 2 shared P. Marrack· 2 shared S. H. Krovi· 2 shared T. Brunetti· 2 shared C. Levens· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersImmunology

L. Loh

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Unraveling the Phenotypic States of Human innate-like T Cells: Comparative Insights with Conventional T Cells and Mouse Models

L. Loh, S. Carcy, H. S. Krovi, J. Domenico, A. Spengler, Y. Lin, J. D. Torres, W. Palmer, P. J. Norman, M. Stone, T. Brunetti, H. V. Meyer, L. Gapin

This study compares human innate-like T cells (Tinn) with conventional T cells and mouse models, revealing distinct transcriptional programs and developmental pathways.

bioRxiv · Dec 7, 2023Immunology

MAIT cells drive chronic inflammation in a genetically diverse murine model of spontaneous colitis.

L. Loh, D. Orlicky, A. Spengler, C. Levens, S. Celli, J. Domenico, J. Klarquist, J. Onyiah, J. Matsuda, K. A. Kuhn, L. Gapin

This study investigates the role of MAIT cells in a genetically diverse mouse model of spontaneous colitis, finding that MAIT cells drive chronic inflammation and colonic pathology.

bioRxiv · Nov 29, 2023 · PreprintImmunology

Single-cell RNA transcriptomics identifies Hivep3 as essential in regulating the development of innate-like T lymphocytes

S. H. Krovi, J. Zhang, M. J. Michaels-Foster, T. Brunetti, L. Loh, J. Scott-Browne, L. Gapin

bioRxiv · Jun 8, 2020 · PreprintImmunology

Tolerance induction in memory CD4 T cells is partial and reversible

J. I. Gray, S. Al Khabouri, F. Morton, E. Clambey, L. Gapin, J. L. Matsuda, J. W. Kappler, P. Marrack, P. Garside, T. D. Otto, M. K. MacLeod

This study shows that memory CD4 T cells can partially tolerate antigen re-exposure but can be reversed by adjuvant-containing reactivation.

bioRxiv · May 25, 2020Immunology

The somatically generated T cell receptor CDR3a contributes to the MHC allele specificity of the T cell receptor

P. Marrack, S. H. Krovi, D. Silberman, J. White, E. Kushnir, M. Nakayama, J. Crook, T. Danhorn, S. Leach, R. Anselment, J. Scott-Browne, L. Gapin, J. Kappler

The paper shows that the somatically generated CDR3a of T cell receptors influences MHC allele specificity during positive selection.

bioRxiv · Aug 15, 2017Immunology