Author

L. Pache

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

A. Garcia-Sastre· 4 shared C. Benner· 4 shared S. Chanda· 4 shared M. W. Chang· 3 shared C. Nguyen· 2 shared J. F. Hultquist· 2 shared J. Guatelli· 2 shared L. Martin-Sancho· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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4 shared papersMicrobiology

A. Garcia-Sastre

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Breakthrough infections by SARS-CoV-2 variants boost cross-reactive hybrid immune responses in mRNA-vaccinated Golden Syrian Hamsters

J. Garcia-Bernalt Diego, G. Singh, S. Jangra, K. Handrejk, M. Laporte, L. A. Chang, S. S. El Zahed, L. Pache, M. W. Chang, P. Warang, S. Aslam, I. Mena, B. T. Webb, C. Benner, A. Garcia-Sastre, M. Schotsaert

This study evaluates hybrid immunity in mRNA-vaccinated hamsters during breakthrough infections, finding enhanced cross-reactive immune responses despite low neutralizing antibody titers.

bioRxiv · May 22, 2023Microbiology

Type I IFN promotes pathogenic inflammatory monocyte maturation during H5N1 infection

S. Fourati, D. Jimenez-Morales, J. F. Hultquist, M. W. Chang, C. Benner, N. J. Krogan, L. Pache, S. Chanda, R.-P. Sekaly, A. Garcia-Sastre, M. B. Uccellini

This study shows that type I IFN promotes the maturation of inflammatory monocytes into pathogenic FasL+MCs during H5N1 infection, contributing to disease severity.

bioRxiv · Jan 10, 2022 · PreprintImmunology

A combined EM and proteomic analysis places HIV-1 Vpu at the crossroads of retromer and ESCRT complexes: PTPN23 is a Vpu-cofactor

C. A. Stoneham, S. Langer, P. De Jesus, J. Wozniak, J. Lapek, T. Deerinck, A. Thor, L. Pache, S. Chanda, D. Gonzalez, M. Ellisman, J. Guatelli

This paper identifies PTPN23 as a Vpu-cofactor and maps Vpu's interactions with retromer and ESCRT complexes using EM and proteomics.

bioRxiv · Feb 22, 2021Microbiology

Functional Landscape of SARS-CoV-2 Cellular Restriction

L. Martin-Sancho, M. K. Lewinski, L. Pache, C. Stoneham, X. YIN, D. Pratt, C. Churas, S. B. Rosenthal, S. Liu, P. D. De Jesus, A. M. O'Neill, A. P. Gounder, C. Nguyen, Y. Pu, A. L. Oom, , S. Chanda

This study identifies key interferon stimulated genes (ISGs) that restrict SARS-CoV-2 infection by inhibiting viral entry, RNA synthesis, and release.

bioRxiv · Sep 29, 2020Microbiology

A Large-scale Drug Repositioning Survey for SARS-CoV-2 Antivirals

L. Riva, S. Yuan, X. Yin, L. Martin-Sancho, N. Matsunaga, S. Burgstaller, L. Pache, P. De Jesus, M. V. Hull, M. Chang, J. F. W. Chan, J. Cao, V. Kwok-Man Poon, K. Herbert, T.-T. Nguyen, , S. Chanda

This study identifies 30 known drugs that inhibit SARS-CoV-2 replication, with six showing effective concentrations likely to be therapeutic in patients.

bioRxiv · Apr 16, 2020 · PreprintMicrobiology