Author

M. Jan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Bioengineering· 1 Pharmacology & Toxicology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Approach:statistical model· 2 Organism:Arabidopsis· 1

Frequent Co-Authors

A. Choudhary· 2 shared B. L. Ebert· 2 shared D. R. Liu· 2 shared V. Sreekanth· 2 shared A. Barrientos· 1 shared A. Deb· 1 shared A. J. Chang· 1 shared A. L. Scharr· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBioengineering

A. Choudhary

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A molecular glue approach to control the half-life of CRISPR-based technologies

V. Sreekanth, M. Jan, K. T. Zhao, D. Lim, J. R. Davis, M. McConkey, V. Kovalcik, S. Barkal, B. K. Law, J. Fife, R. Tian, M. E. Vinyard, B. Becerra, M. E. Kampmann, R. I. Sherwood, , A. Choudhary

This paper introduces a molecular glue approach using pomalidomide to control the half-life of CRISPR-based technologies, enabling precise regulation of their activity and therapeutic potential.

bioRxiv · Mar 12, 2023Bioengineering

Identification of two bZIP transcription factors that regulate development of pavement and trichome cells in Arabidopsis thaliana by single-cell RNA-sequencing

R. Wu, Z. Liu, J. Wang, W. Li, A. Qin, X. Yu, H. Liu, C. Guo, Z. Zhao, Y. Zhang, Y. Zhou, S. Sun, Y. Liu, M. Hu, J. Yang, , X. Sun

This study identifies bZIP25 and bZIP53 as transcription factors regulating pavement and trichome cell development in Arabidopsis thaliana using single-cell RNA-sequencing.

bioRxiv · Apr 12, 2022 · PreprintPlant Biology

Proteolysis Targeting Chimeras With Reduced Off-targets

T. M. Nguyen, V. Sreekanth, A. Deb, P. Kokkonda, P. K. Tiwari, K. A. Donovan, V. M. Shoba, S. K. Chaudhary, J. A. M. Mercer, S. Lai, A. Sadagopan, M. Jan, E. S. Fischer, D. R. Liu, B. L. Ebert, A. Choudhary

This study develops a platform to identify off-target degradation of ZF proteins by PROTACs and identifies design rules to reduce off-target effects using pomalidomide analogs.

bioRxiv · Nov 18, 2021Pharmacology & Toxicology

A mitochondrial electron transport chain with atypical subunit composition confers oxygen sensitivity to a mammalian chemoreceptor

A. Timon-Gomez, A. L. Scharr, N. Y. Wong, E. Ni, A. Roy, M. Liu, J. Chau, J. L. Lampert, H. Hireed, N. S. Kim, M. Jan, A. R. Gupta, R. W. Day, J. M. Gardner, R. J. Wilson, , A. J. Chang

This study identifies HIGD1C as a novel ETC Complex IV subunit in carotid body glomus cells that enhances hypoxia sensitivity, contributing to oxygen sensing and potential therapeutic targets for CB-related diseases.

bioRxiv · Oct 4, 2021 · PreprintPhysiology

The sleep-wake distribution contributes to the peripheral rhythms in PERIOD-2

M. M. B. Hoekstra, M. Jan, Y. Emmenegger, P. Franken

This study shows that sleep-wake patterns influence PER2 rhythms in peripheral tissues, with mathematical modeling supporting a dual-force mechanism involving sleep-wake and SCN-independent circadian inputs.

bioRxiv · Jul 25, 2020Physiology