Author

R. Singhal

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cancer & tumor microenvironment· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:metabolism & bioenergetics· 2 Assay:metabolomics· 2 Organism:mouse· 2

Frequent Co-Authors

C. A. Lyssiotis· 4 shared Y. M. Shah· 4 shared A. Andren· 2 shared H. Bell· 2 shared N. K. Das· 2 shared R. Banerjee· 2 shared R. Kumar· 2 shared A. E. Taylor· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersCancer Biology

C. A. Lyssiotis

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Inhibition of the glucocorticoid-activating enzyme 11β-hydroxysteroid dehydrogenase type 1 drives concurrent 11-oxygenated androgen excess

L. Schiffer, I. Oestlund, J. Snoep, L. C. Gilligan, A. E. Taylor, A. J. Sinclair, R. Singhal, A. Freeman, R. Ajjan, A. Tiganescu, W. Arlt, K.-H. Storbeck

This study shows that inhibiting HSD11B1 increases 11-ketotestosterone levels in adipose tissue and circulation, potentially offsetting benefits of reduced glucocorticoid activation in women.

bioRxiv · Jun 5, 2023Biochemistry

Sulfide oxidation promotes hypoxic angiogenesis and neovascularization

R. Kumar, V. Vitvitsky, P. Seth, H. L. Hiraki, H. Bell, A. Andren, R. Singhal, B. Baker, C. A. Lyssiotis, Y. M. Shah, R. Banerjee

This study shows that sulfide oxidation via SQOR promotes hypoxic angiogenesis and neovascularization by reprogramming metabolic pathways in endothelial cells.

bioRxiv · Mar 14, 2023Biochemistry

PINK1 supports colorectal cancer growth by regulating the labile iron pool.

B. Chen, N. K. Das, I. Talukdar, R. Singhal, C. Castillo, A. Andren, J. D. Mancias, C. A. Lyssiotis, Y. M. Shah

This study shows PINK1 supports colorectal cancer growth by regulating the labile iron pool through mitophagy and ferritinophagy.

bioRxiv · Sep 27, 2022 · PreprintCancer Biology

Microenvironmental Ammonia Enhances T cell Exhaustion in Colorectal Cancer

Y. M. Shah, H. Bell, A. K. Huber, R. Singhal, R. J. Rebernick, R. Kumar, N. K. Das, S. A. Kerk, P. Sajjakulnukit, S. Solanki, J. G. James, D. Kim, L. Zhang, M. O. El-derany, T. L. Frankel, , M. Green

This study shows that ammonia accumulation in the colorectal cancer microenvironment promotes T cell exhaustion and treatment resistance, and that reducing ammonia improves immunotherapy efficacy.

bioRxiv · May 25, 2022Cancer Biology

Hypoxia inducible factor-2α increases sensitivity of colon cancer cells towards oxidative cell death

R. Singhal, K. P. Olive, C. A. Lyssiotis, Y. M. Shah

This study shows that HIF-2α overexpression makes colon cancer cells more sensitive to oxidative cell death, suggesting a potential therapeutic strategy.

bioRxiv · Oct 30, 2019 · PreprintCancer Biology