Author

L.-I. McCall

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 5 Microbiology· 5

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 9 Assay:metabolomics· 8 Organism:mouse· 6 Research Focus:host-pathogen & immune response· 5 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:ecology & biodiversity· 2 Approach:deep learning· 1

Frequent Co-Authors

E. Hossain· 7 shared D. A. Dean· 4 shared M. Katemauswa· 4 shared A. R. Parab· 3 shared D. Thomas· 3 shared Z. Liu· 3 shared J. H. McKerrow· 2 shared J. L. Siqueira-Neto· 2 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

7 shared papersMicrobiology

E. Hossain

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Persistent biofluid small molecule alterations induced by Trypanosoma cruzi infection are not restored by antiparasitic treatment

D. A. Dean, J. Roach, R. Ulrich vonBargen, Y. Xiong, S. S. Kane, L. Klechka, K. Wheeler, M. Jimenez Sandoval, M. Lesani, E. Hossain, M. Katemauswa, M. Schaefer, M. Harris, S. Barron, Z. Liu, , L.-I. McCall

This study identifies persistent urine metabolome alterations in T. cruzi-infected mice that are not reversed by antiparasitic treatment, suggesting urine as a potential diagnostic tool for Chagas Disease.

bioRxiv · Jun 3, 2023Microbiology

Spatial metabolomics reveals localized impact of influenza virus infection on the lung tissue metabolome

D. A. Dean, L. Klechka, E. Hossain, A. R. Parab, K. Eaton, M. Hinsdale, L.-I. McCall

This study uses spatial metabolomics to analyze metabolic changes in lung tissue and plasma of influenza-infected mice, identifying site-specific metabolite alterations and their potential as therapeutic targets.

bioRxiv · Nov 22, 2021Microbiology

Optimized extraction method enables quantitative analysis of surface metabolite recovery for exposomics and behavioral studies

M. Katemauswa, E. Hossain, Z. Liu, M. Lesani, A. R. Parab, D. A. Dean, L.-I. McCall

This study develops a swab-based method to quantitatively measure small molecule recovery on surfaces, demonstrating its use for exposomics and behavioral analysis.

bioRxiv · Aug 25, 2021Biochemistry

Identification of Leucinostatins from Ophiocordyceps sp. as Antiparasitic Agents Against Trypanosoma cruzi

J. A. Bernatchez, Y.-S. Kil, E. Barbosa da Silva, D. Thomas, L.-I. McCall, K. L. Wendt, J. M. Souza, J. Ackermann, J. H. McKerrow, R. H. Cichewicz, J. L. Siqueira-Neto

This study identifies leucinostatins from fungi as potent antiparasitic agents against Trypanosoma cruzi, with one showing in vivo efficacy in a mouse model.

bioRxiv · May 30, 2021Microbiology

The Core Human Fecal Metabolome

J. Haffner, M. Katemauswa, T. S. Kagone, E. Hossain, D. Jacobson, K. Flores, A. R. Parab, A. J. Obregon-Tito, R. Y. Tito, L. Marin Reyes, L. Troncoso-Corzo, E. Guija-Poma, N. Meda, H. Carabin, T. P. Honap, , L.-I. McCall

This study characterizes the core human fecal metabolome through untargeted metabolomic analysis of populations along an industrialization gradient, revealing shared and industrialization-related metabolites.

bioRxiv · May 8, 2021Biochemistry

Alterations to the cardiac metabolome induced by chronic T. cruzi infection relate to the degree of cardiac pathology

K. A. Hoffman, P. J. Hotez, M. E. Bottazzi, E. Hossain, Z. Liu, K. M. Jones, L.-I. McCall

This study examines metabolomic changes in the heart during chronic T. cruzi infection, linking metabolic alterations to cardiac fibrosis and inflammation.

bioRxiv · Sep 17, 2020Microbiology

Spatial metabolomics identifies localized chemical changes in heart tissue during chronic cardiac Chagas disease

D. A. Dean, Gautham, J. L. Siqueira-Neto, J. H. McKerrow, P. C. Dorrestein, L.-I. McCall

The paper uses spatial metabolomics to identify localized metabolic changes in heart tissue of mice chronically infected with Trypanosoma cruzi, revealing distinct metabolic perturbations from parasite burden sites.

bioRxiv · Jun 29, 2020Biochemistry

Metabolite profiling of experimental cutaneous leishmaniasis lesions demonstrates significant perturbations in tissue phospholipids

L.-I. McCall, A. Parab, J. McKerrow, P. C. Dorrestein, D. Thomas, S. Lostracco-Johnson, J. L. de Siquiera-Neto

This study uses metabolomics to show significant changes in phospholipids in cutaneous leishmaniasis lesions and adjacent healthy tissue in mice.

bioRxiv · May 13, 2020Biochemistry

3D mapping of host-parasite-microbiome interactions reveals metabolic determinants of tissue tropism and disease tolerance in Chagas disease

E. Hossain, S. Khanam, C. Wu, S. Lostracco-Johnson, D. Thomas, M. Katemauswa, C. Gosmanov, D. Li, C. Woelfel-Monsivais, K. Sankaranarayanan, L.-I. McCall

This study maps host-parasite-microbiome interactions in Chagas disease, identifying metabolic factors that influence tissue tropism and disease tolerance.

bioRxiv · Aug 9, 2019Microbiology

Characterization of the workplace chemical exposome using untargeted LC-MS/MS: a case study

L.-I. McCall, V. M. Anderson, R. S. Fogle, J. J. Haffner, E. Hossain, R. Liu, A. H. Ly, H. Ma, M. Nadeem, S. Yao

This study uses untargeted LC-MS/MS to analyze chemical exposures in three workplace types, identifying how building purpose, surface materials, and location affect chemical signatures and human exposure.

bioRxiv · Feb 5, 2019Biochemistry