E. Hossain

Persistent biofluid small molecule alterations induced by Trypanosoma cruzi infection are not restored by antiparasitic treatment

This study identifies persistent urine metabolome alterations in T. cruzi-infected mice that are not reversed by antiparasitic treatment, suggesting urine as a potential diagnostic tool for Chagas Disease.

A high-throughput multiplex array for antigen-specific serology with automated analysis.

The paper describes a high-throughput CBA system for antigen-specific serology with automated analysis tools to quantify IgM, IgA, and IgG concentrations.

Spatial metabolomics reveals localized impact of influenza virus infection on the lung tissue metabolome

This study uses spatial metabolomics to analyze metabolic changes in lung tissue and plasma of influenza-infected mice, identifying site-specific metabolite alterations and their potential as therapeutic targets.

Optimized extraction method enables quantitative analysis of surface metabolite recovery for exposomics and behavioral studies

This study develops a swab-based method to quantitatively measure small molecule recovery on surfaces, demonstrating its use for exposomics and behavioral analysis.

The Core Human Fecal Metabolome

This study characterizes the core human fecal metabolome through untargeted metabolomic analysis of populations along an industrialization gradient, revealing shared and industrialization-related metabolites.

Alterations to the cardiac metabolome induced by chronic T. cruzi infection relate to the degree of cardiac pathology

This study examines metabolomic changes in the heart during chronic T. cruzi infection, linking metabolic alterations to cardiac fibrosis and inflammation.

3D mapping of host-parasite-microbiome interactions reveals metabolic determinants of tissue tropism and disease tolerance in Chagas disease

This study maps host-parasite-microbiome interactions in Chagas disease, identifying metabolic factors that influence tissue tropism and disease tolerance.

Characterization of the workplace chemical exposome using untargeted LC-MS/MS: a case study

This study uses untargeted LC-MS/MS to analyze chemical exposures in three workplace types, identifying how building purpose, surface materials, and location affect chemical signatures and human exposure.

Elevation of intracellular levels of nitric oxide in SHR attenuates hyperproliferation of vascular smooth muscle cells through the inhibition of AT1 receptor expression and c-Src/growth factor receptor signaling pathways

This study shows that increasing intracellular nitric oxide in SHR reduces VSMC hyperproliferation by inhibiting AT1 receptor and growth factor receptor signaling pathways.