Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
5 papers
Recent·Most cited
E. L. Dearlove, C. Chatrin, L. Buetow, S. F. Ahmed, T. Schmidt, M. Bushell, B. O. Smith, D. T. Huang
This study shows that DTX3L ubiquitinates single-stranded DNA and RNA, expanding the known substrates of ubiquitination beyond proteins.
bioRxiv · Apr 2, 2024Biochemistry
J. A. Waldron, G. Kanellos, R. C. L. Smith, J. R. P. Knight, J. Munro, C. Alexandrou, N. Vlahov, L. Pardo-Fernandez, M. Moore, S. L. Gillen, D. Strathdee, D. Stevenson, F. C. Warrander, K. Gilroy, C. Nixon, , O. J. Sansom
This study shows eIF4A1 is critical for supporting translational demands in Wnt-driven colorectal cancers, while eIF4A2 loss accelerates tumourigenesis, and eFT226 inhibits eIF4A1 function in these models.
bioRxiv · Nov 10, 2023 · PreprintCancer Biology
M. Moore, L. Pardo, L. Mitchell, T. Schmidt, J. Waldron, S. May, M. Mueller, R. Smith, D. Strathdee, S. Bryson, K. Hodge, S. Lilla, A. Wilczynska, L. McGarry, S. Gillen, , J. C. Norman
The paper shows that eIF4A2, a negative regulator of mRNA translation, promotes ECM deposition to accelerate HCC initiation by influencing integrin-mediated signaling and senescence exit.
bioRxiv · Aug 16, 2023 · PreprintCancer Biology
J. Chettle, Z. Dedeic, R. Fischer, I. Vendrell, L. Campo, A. Easton, M. Browne, J. Morris, H. Schwenzer, P. Lascaux, R. Gijsbers, E. Pires, D. J. Royston, D. J. P. Ferguson, A. Coosemans, , S. P. Blagden
This study identifies LARP1 as a key regulator of metabolism and mTORC1 activity in cancer, showing its role in sustaining cellular metabolism and driving cancer progression.
bioRxiv · Sep 4, 2022 · PreprintCancer Biology
A. S. Bader, J. Luessing, B. R. Hawley, G. L. Skalka, W.-T. Lu, N. F. Lowndes, M. Bushell
This study identifies DDX17 as essential for DNA repair at loci deficient in DNA:RNA hybrids by promoting hybrid formation at DSB sites.
bioRxiv · Oct 14, 2021Cell Biology