M. Chien

Combination of Antiviral Drugs to Inhibit SARS-CoV-2 Polymerase and Exonuclease as Potential COVID-19 Therapeutics

This study identifies HCV NS5A inhibitors as SARS-CoV-2 exonuclease inhibitors and shows synergy in combination with polymerase inhibitors to enhance antiviral efficacy.

Sofosbuvir Terminated RNA is More Resistant to SARS-CoV-2 Proofreader than RNA Terminated by Remdesivir

This study compares the resistance of SARS-CoV-2 RNA terminated by Sofosbuvir and Remdesivir to exonuclease proofreading, finding Sofosbuvir-terminated RNA more resistant.

A Library of Nucleotide Analogues Terminate RNA Synthesis Catalyzed by Polymerases of Coronaviruses Causing SARS and COVID-19

This paper evaluates nucleotide analogues as inhibitors of SARS-CoV and SARS-CoV-2 RdRp, identifying those that terminate RNA synthesis and resist viral exonuclease activity.

Triphosphates of the Two Components in DESCOVY and TRUVADA are Inhibitors of the SARS-CoV-2 Polymerase

The paper shows that the triphosphates of tenofovir and emtricitabine inhibit SARS-CoV-2 RNA-dependent RNA polymerase, suggesting potential use of DESCOVY and TRUVADA as PrEP for COVID-19.

Mechanosensation Mediates Long-Range Spatial Decision-Making in an Aneural Organism

This paper shows that the aneural protist Physarum polycephalum uses mechanosensation to preferentially grow toward heavier, chemically inert masses, revealing a novel biomechanical decision-making mechanism.

Nucleotide Analogues as Inhibitors of SARS-CoV-2 Polymerase

This study shows that three nucleotide analogues inhibit SARS-CoV-2 polymerase by being incorporated and blocking further RNA synthesis.

Novel cytokine interactions identified during perturbed hematopoiesis

The paper identifies 61 previously unreported cytokine relationships using convergent cross-mapping in a patient with cyclic thrombocytopenia.