Author

A. Garzia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Cell Biology· 1 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

T. Tuschl· 3 shared C. Meyer· 2 shared P. Naeli· 2 shared S. M. Jafarnejad· 2 shared T. Alain· 2 shared A. C. H. Liu· 1 shared A. Hackett· 1 shared C. Adrain· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersCell Biology

T. Tuschl

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Ribosome Quality Control Mechanism Mitigates the Cytotoxic Impacts of Ribosome Collisions Induced by 5-Fluorouracil

S. Chatterjee, P. Naeli, N. Simms, A. Garzia, A. Hackett, K. Coyle, P. Harris Snell, T. McGirr, T. N. Sawant, K. Dang, Z. V. Stoichkova, T. Alain, T. Tuschl, S. S. McDade, D. Longley, , S. M. Jafarnejad

This study shows that 5-Fluorouracil induces ribosome collisions, which are mitigated by the RQC mechanism through mTOR-dependent regulation of RQC factors.

bioRxiv · Dec 26, 2023Cell Biology

SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translation

J.-H. Choi, X. Zhang, C. Zhang, D. L. Dai, J. Luo, R. Ladak, Q. Li, S. Wiebe, A. C. H. Liu, X. Ran, J. Yang, P. Naeli, A. Garzia, L. Zhou, N. Mahmood, , N. Sonenberg

This study identifies NSP2-induced repression of Ifnb1 mRNA translation as a mechanism by which SARS-CoV-2 suppresses IFN-β production.

bioRxiv · Jan 19, 2022 · PreprintMicrobiology

Heat-inactivated modified vaccinia virus Ankara boosts Th1-biased cellular and humoral immune responses as a vaccine adjuvant by activating the STING-mediated cytosolic DNA-sensing pathway

N. Yang, A. Garzia, C. Meyer, T. Tuschl, T. Merghoub, J. Wolchok, L. Deng

This study shows heat-inactivated MVA enhances Th1 immune responses by activating the STING pathway and improves antitumor efficacy when combined with antigens.

bioRxiv · Jul 24, 2021 · PreprintImmunology

Combination of Antiviral Drugs to Inhibit SARS-CoV-2 Polymerase and Exonuclease as Potential COVID-19 Therapeutics

X. Wang, C. Q. Sacramento, S. Jockusch, O. A. Chaves, C. Tao, N. Fintelman-Rodrigues, M. Chien, J. R. Temerozo, X. Li, S. Kumar, W. Xie, D. J. Patel, C. Meyer, A. Garzia, T. Tuschl, , J. Ju

This study identifies HCV NS5A inhibitors as SARS-CoV-2 exonuclease inhibitors and shows synergy in combination with polymerase inhibitors to enhance antiviral efficacy.

bioRxiv · Jul 21, 2021 · PreprintPharmacology & Toxicology

Defining the transcriptional responses of Aspergillus nidulans to cation/alkaline pH stress and the role of the transcription factor SltA.

I. Picazo, O. Etxebeste, E. Requena, A. Garzia, E. A. Espeso

This study uses RNA sequencing to analyze the transcriptional responses of Aspergillus nidulans to alkaline pH and sodium stress, revealing SltA's broader role in stress response pathways.

bioRxiv · Apr 16, 2020Microbiology