Author

T. Tuschl

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biochemistry· 1 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

A. Garzia· 3 shared C. Meyer· 2 shared A. Hackett· 1 shared A. Pitiriciu· 1 shared Acclerating Medicine Partnership (AMP)· 1 shared B. Goilav· 1 shared C. Adrain· 1 shared C. G. Gkogkas· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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3 shared papersCell Biology

A. Garzia

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Ribosome Quality Control Mechanism Mitigates the Cytotoxic Impacts of Ribosome Collisions Induced by 5-Fluorouracil

S. Chatterjee, P. Naeli, N. Simms, A. Garzia, A. Hackett, K. Coyle, P. Harris Snell, T. McGirr, T. N. Sawant, K. Dang, Z. V. Stoichkova, T. Alain, T. Tuschl, S. S. McDade, D. Longley, , S. M. Jafarnejad

This study shows that 5-Fluorouracil induces ribosome collisions, which are mitigated by the RQC mechanism through mTOR-dependent regulation of RQC factors.

bioRxiv · Dec 26, 2023Cell Biology

Heat-inactivated modified vaccinia virus Ankara boosts Th1-biased cellular and humoral immune responses as a vaccine adjuvant by activating the STING-mediated cytosolic DNA-sensing pathway

N. Yang, A. Garzia, C. Meyer, T. Tuschl, T. Merghoub, J. Wolchok, L. Deng

This study shows heat-inactivated MVA enhances Th1 immune responses by activating the STING pathway and improves antitumor efficacy when combined with antigens.

bioRxiv · Jul 24, 2021 · PreprintImmunology

Combination of Antiviral Drugs to Inhibit SARS-CoV-2 Polymerase and Exonuclease as Potential COVID-19 Therapeutics

X. Wang, C. Q. Sacramento, S. Jockusch, O. A. Chaves, C. Tao, N. Fintelman-Rodrigues, M. Chien, J. R. Temerozo, X. Li, S. Kumar, W. Xie, D. J. Patel, C. Meyer, A. Garzia, T. Tuschl, , J. Ju

This study identifies HCV NS5A inhibitors as SARS-CoV-2 exonuclease inhibitors and shows synergy in combination with polymerase inhibitors to enhance antiviral efficacy.

bioRxiv · Jul 21, 2021 · PreprintPharmacology & Toxicology

Assembly defects of the human tRNA splicing endonuclease contribute to impaired pre-tRNA processing in pontocerebellar hypoplasia

S. Sekulovski, P. Devant, S. Panizza, T. Gogakos, A. Pitiriciu, K. Heitmeier, E. P. Ramsay, M. Barth, C. Schmidt, S. Weitzer, T. Tuschl, F. Baas, J. Martinez, S. Trowitzsch

This study shows that TSEN assembly defects in PCH patients impair pre-tRNA processing by reducing cleavage activity despite normal endonuclease activity.

bioRxiv · Aug 3, 2020Biochemistry

Insights from Comparison of the Renal and Skin Single Cell Transcriptomes in Lupus Nephritis

E. Der, H. Suryawanshi, P. Morozov, M. Kustagi, B. Goilav, S. Ranabathou, P. Izmirly, R. Clancy, H. M. Belmont, M. Koenigsberg, M. Mokrzycki, H. Rominieki, J. Graham, J. Rocca, N. Bornkamp, , C. Putterman

This study uses scRNA-seq to analyze renal and skin biopsies from lupus nephritis patients, identifying IFN signatures and fibrotic pathways associated with disease heterogeneity and non-response.

bioRxiv · Dec 31, 2019 · PreprintImmunology