H. Mo

Mechano-regulation of GLP-1 production by Piezo1 in intestinal L cells

This study shows that Piezo1 in intestinal L cells mechanically regulates GLP-1 production, affecting glucose tolerance and diabetes.

Tumors cells with mismatch repair deficiency induce hyperactivation of Pyroptosis resistant to cell membrane damage but are more sensitive to Co-treatment of IFN-γ and TNF-α to PANoptosis

The paper shows that dMMR tumor cells are resistant to membrane damage but sensitive to IFN-γ and TNF-α co-treatment inducing PANoptosis, suggesting a strategy to enhance ICB therapy.

Transgene by Germplasm Interactions Can Impact Transgene Evaluation

This study evaluates how genetic background affects transgene performance in maize, finding variable yield impacts across different hybrid combinations.

Methods for Evaluating Effects of Transgenes for Quantitative Traits

This study evaluates three methods for estimating transgene effects across genetic backgrounds and environments, finding that bulked F3 lines topcrossed to a tester inbred provide the most effective approach.

Remdesivir and GS-441524 retain antiviral activity against Delta, Omicron, and other emergent SARS-CoV-2 variants

This study assesses the antiviral activity of remdesivir and GS-441524 against multiple SARS-CoV-2 variants, finding they remain effective against Delta, Omicron, and other variants.

Spatially Resolved Phosphoproteomics Reveals Fibroblast Growth Factor Receptor Recycling-driven Regulation of Autophagy and Survival

The paper uses spatially resolved phosphoproteomics to show FGFR2b recycling activates mTOR and ULK1, suppressing autophagy and promoting cell survival in cancer cells.

The gut microbial signature of gestational diabetes mellitus and the association with diet intervention

This study examines gut microbiota composition in GDM patients before and after diet intervention, finding that diet affects the Firmicutes/Bacteroidetes ratio and specific taxa rather than altering the overall microbial pattern.